Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

By Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis, Lori A. Sturtz, P. Defossez, V. Culotta, Gerald Fink, L. Guarente. Nature, 2002

1,116 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/55877f7c574b4686c98e70b96971722c1593ba9f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. C. Kenyon
3. D. Sinclair
4. Brian K. Kennedy
5. M. Haigis
6. V. Longo
7. Johan Auwerx
8. Toren Finkel

In Geriatrics and Gerontology

1. L. Guarente
2. D. Sinclair
3. Johan Auwerx
4. M. Haigis
5. C. Cantó
6. R. Houtkooper
7. Brian K. Kennedy
8. V. Longo

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. L. Guarente
4. C. Cantó
5. R. Houtkooper
6. M. Haigis
7. C. Kenyon
8. Brian K. Kennedy

Citations in the corpus

• A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis (2008, background): “In yeast, Sir2 is involved in transcriptional silencing and acts as a regulator of life span (1, 2).”
• Metabolic regulation of epigenetics (2012, background): “One potential mechanism is that CR in yeast increases respiration and therefore generates a more oxidized environment and a high NAD+/NADH ratio (Lin et al., 2002).”
• Caloric restriction. (2011, background): “…can shift their metabolism in response to environmental perturbations between respiration and fermentation, an alternative unavailable to mammals (Lin et al., 2002), (b) Nematode worms, flies and mammals have in common responses to CR that include changes in glucose homeostasis and insulin…”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “This shift is both necessary and sufficient to increase life span (Lin et al., 2002).”
• Neural mechanisms of ageing and cognitive decline (2010, background): “Furthermore, artificially elevating the rate of mitochondrial respiration is sufficient to increase replicative lifespan in yeas”
• Body size, energy metabolism and lifespan (2005, background): “(ii) Studies of different strains Lin et al. (2002) observed that yeast under caloric restriction varied in their lifespans such that those with the longest lives also had the highest metabolic rates.”
• Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (2004, background): “…not only for alterations in gene expression butSummary also for repression of ribosomal DNA recombination and extension of lifespan in response to calorie restrictionNAD is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of (Lin et al., 2000, 2002).”
• SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009, positive): “In yeast, C. elegans, and Drosophila, SIR2 orthologs slow aging and respond to metabolic conditions (Kaeberlein et al., 1999; Lin et al., 2002; Rogina and Helfand, 2004; Tissenbaum and Guarente, 2001; Wang et al., 2006).”
• An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “Finally, the sir-2 gene has been shown to be important to mediate certain forms of DR in a variety of species from yeast to flies [38–41], though this observation is still subject to debate [24,25,42,43].”