Neural mechanisms of ageing and cognitive decline

By Nicholas A. Bishop, Tao Lu, B. Yankner. Nature, 2010

1,288 citations recorded by the source corpus.

During the past century, treatments for the diseases of youth and middle age have helped raise life expectancy significantly. However, cognitive decline has emerged as one of the greatest health threats of old age, with nearly 50% of adults over the age of 85 afflicted with Alzheimer's disease. Developing therapeutic interventions for such conditions demands a greater understanding of the processes underlying normal and pathological brain ageing. Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a19204eb07fad92d7cad4384ad1718389537de4e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Mark P. Mattson
2. Linda Partridge
3. V. Longo
4. D. Sinclair
5. T. Horvath
6. T. Niccoli
7. Luigi Fontana

In Molecular Biology

1. Linda Partridge
2. T. Niccoli
3. D. Sinclair
4. Mark P. Mattson
5. C. Zhong
6. T. Horvath
7. V. Longo
8. Zhichun Chen

In Physiology

1. Mark P. Mattson
2. V. Longo
3. Linda Partridge
4. D. Sinclair
5. C. Zhong
6. T. Horvath
7. Zhichun Chen
8. T. Niccoli

Citations in the corpus

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• Fasting: Molecular Mechanisms and Clinical Applications (2014, background): “Major factors implicated in aging whose generation are accelerated by gluttonous lifestyles and slowed by energy restriction in humans include the following: (1) oxidative damage to proteins, DNA, and lipids; (2) inflammation; (3) accumulation of dysfunctional proteins and organelles; and (4) elevat”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Moreover, Sir2 has no effect on yeast survival under starvation (97) or in worms under CR (41).”