Metabolic regulation of epigenetics

By Chao Lu, Craig B. Thompson. Cell Metabolism, 2012

657 citations recorded by the source corpus.

How cells sense and respond to environmental cues remains a central question of biological research. Recent evidence suggests that DNA transcription is regulated by chromatin organization. However, the mechanism for relaying the cytoplasmic signaling to chromatin remodeling remains incompletely understood. Although much emphasis has been put on delineating transcriptional output of growth factor/hormonal signaling pathways, accumulated evidence from yeast and mammalian systems suggest that metabolic signals also play critical roles in determining chromatin structure. Here we summarize recent progress in understanding the molecular connection between metabolism and epigenetic modifications of chromatin implicated in a variety of diseases including cancer.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2b0a8f1b048c1585b517c9164eff3c7a86e2cab3

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Citations in the corpus

Mitochondria and Cancer (2016, background): “Oncometabolitedriven changes in the epigenome suppress differentiation and promote proliferation (Dang et al., 2009; Lu and Thompson, 2012; Parker and Metallo, 2015).”
The Warburg Effect: How Does it Benefit Cancer Cells? (2016, background): “Also, the NAD[54_TD$DIFF]:NADH ratio increases in nutrient-deprived conditions [39,56,57].”
Metabolic Regulation of Gene Expression by Histone Lysine β-hydroxybutyrylation (2016, positive): “Increasing evidence implicates altered histone modifications in translating cellular metabolic states into changes in gene expression (Kaelin and McKnight, 2013; Katada et al., 2012; Lu and Thompson, 2012).”
Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate. (2014, background): “, nutrition levels) can have a lasting effect on gene expression patterns, it has been suggested that metabolites and small cellular molecules have an immediate impact on the condition of chromatin and the epigenetic state of cells (Lu and Thompson, 2012).”
Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism (2016, background): “Glucose metabolism is implicated in the control of gene expression through epigenetic mechanisms including histone acetylation (7, 22).”
Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5 (2014, background): “Indeed, several mechanisms have been described bywhich cells adapt to such environmental changes, such as transcriptional regulation by alterations of epigenetic marks, modulation of metabolic enzyme activities by cellular metabolites, and protein posttranslational modifications (PTMs) (Furuya and U”
Thyroid hormone regulation of metabolism. (2014, background): “Coactivator recruits enzymes that acetylate histones and promote transcription, a process sensitive to the metabolic state of the cell (71, 165).”
T cell metabolism drives immunity (2015, background): “Acetylation also affects the activity of circadian clock proteins, and reciprocally, the circadian acetylome has been found to regulate the epigenome and mitochondrial metabolic pathways (Koike et al., 2012; Lu and Thompson, 2012; Masri et al., 2013).”
Class I histone deacetylases (HDAC1–3) are histone lysine delactylases (2021, background): “Other metabolites, such as nicotinamide adenine dinucleotide (NAD+) and -ketoglutarate, can serve as cofactors and regulate the activities of corresponding deacetylases and demethylases (5).”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, neutral): “Cellular mechanisms by which metabolic changes can be communicated to chromatin are being increasingly discussed (Gut and Verdin, 2013; Katada et al., 2012; Lu and Thompson, 2012).”