Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.

By P. Bieganowski, Charles Brenner. Cell, 2004

708 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/0560a397f6505e6055bab0ff7f9dc4276f449569

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. C. Cantó
3. D. Sinclair
4. Joseph A. Baur
5. R. Houtkooper
6. Keir J. Menzies
7. W. Kraus
8. E. Pirinen

In Oncology

1. Johan Auwerx
2. C. Cantó
3. Joseph A. Baur
4. W. Kraus
5. D. Sinclair
6. R. Houtkooper
7. S. Imai

In Physiology

1. Johan Auwerx
2. C. Cantó
3. D. Sinclair
4. Joseph A. Baur
5. R. Houtkooper
6. Keir J. Menzies
7. E. Pirinen
8. W. Kraus

Citations in the corpus

• NAD+ intermediates: The biology and therapeutic potential of NMN and NR (2017, neutral): “Interestingly, recent studies have documented both at micromolar concentrations in human and cow milk (Bieganowski and Brenner, 2004; Ummarino et al., 2017).”
• Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. (2007, background): “Although we cannot and do not rule out other mechanisms by which mitochondria obtain NAD, such as NAD import or via alternative NAD biosynthetic routes (Bieganowski and Brenner, 2004), the fact that Nampt activity is required to maintain NAD levels in isolated mitochondria is strong evidence that Na”
• Sirtuins as regulators of metabolism and healthspan (2012, background): “Interestingly, nicotinamide riboside, which is found in milk and is already known to boost NAD + synthesis in bacteria, was recently shown to act as a NAD + precursor and to enhance NAD + synthesis through the salvage pathway in eukaryotic cell”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “Lastly, NRmetabolism constitutes an additional path for NAD+ biosynthesis (Bieganowski and Brenner, 2004) (Figure 1D).”
• The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity (2012, neutral): “S4B), NRK2 was mainly present in cardiac and skeletal muscle tissues, as previously described (Li et al., 1999), but also detectable in BAT and liver (Fig.”
• The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “The discovery of NR as a nutrient in cow milk (43) poses an interesting opportunity for therapeutic intervention in NAD -dependent metabolism, as will be discussed in Section IX.”
• Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal. (2005, background): “Recently, nicotinamide riboside was also shown to be a precursor for NAD synthesis, connecting to the nicotinamide salvage pathway through NMN (Fig. 4; Bieganowski and Brenner 2004).”
• CD38 dictates age-related NAD decline and mitochondrial dysfunction through a SIRT3-dependent mechanism (2016, neutral): “However, since NR is converted to NMN (Bieganowski and Brenner, 2004; Grozio et al., 2013), it is still possible that CD38 may have a role in NR-mediated pharmacokinetics.”