The role of oxidative stress in carcinogenesis.

By J. Klaunig, L. Kamendulis. Annual Review of Pharmacology and Toxicology, 2004

1,577 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5325b9d5cae65dd5701e4131731c221303d7f399

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Citations in the corpus

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development (2011, positive): “…(Plug-DeMaggio et al., 2004), hypoxia (Coquelle et al., 1998), defective DNA damage repair (Duensing and Münger, 2002), chromosomal segregation errors (Duensing et al., 2000), abrogated mitotic checkpoints (Thompson et al., 1997), and reactive oxygen species (Klaunig and Kamendulis, 2004).”
Superoxide Flashes in Single Mitochondria (2008, neutral): “Depending on concentration, location and context, ROS can be either ‘‘friends’’ or ‘‘foes.’’ Excessive ROS generation leads to apoptotic and necrotic cell death (Brookes et al., 2004; Dypbukt et al., 1994) and pathogenesis of a panel of clinically distinct disorders including neurodegeneration (e.g.”
Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise (2008, positive): “Glutathione peroxidases, localized in the cytosol and mitochondria, remove the majority of hydrogen peroxide, whereas catalase, located in peroxisomes, is responsible for the removal of high levels of hydrogen per-oxide (155).”
Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. (2007, background): “It is recognized that the cellular production of O ÿ 2 and H2O2 favors the formation of other reactive oxygen and nitrogen species – such as hydroxyl radical (OH ) and peroxynitrite (ONOOÿ) – and that an excessive production of these species causes oxidative stress and may play an important role in ”
Phenolic Profile and Antioxidant Activity of Crude Extracts from Microalgae and Cyanobacteria Strains (2017, background): “Several studies on pharmacological research have evidenced that oxidative stress and increased amounts of free radicals are features of chronic diseases including cancer [2], aging, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s [3, 4] and cardiovascular diseases such as atherosc”
Studies on free radicals, antioxidants, and co-factors (2007, background): “It has been observed that that oxidation of dopamine yields potentially toxic semiquinones and that the accelerated metabolism of dopamine by monoamine-oxidase-B may induce an excessive formation of hydrogen peroxide, superoxide anions, and hydroxyl radicals.”
Distribution and biological activities of the flavonoid luteolin. (2009, background): “A growing body of research suggests that ROS play a crucial role in cancer development [141-143].”
Oxidative stress, DNA methylation and carcinogenesis. (2008, background): “For instance, activation of specialized macrophages in liver known as Kupffer cells has been implicated in tumor promotion through ROS release [1].”
A review on the dietary flavonoid kaempferol. (2011, background): “The ability of kaempferol to decrease superoxide levels at low concentrations may play an important role in its antioxidant activity, as the formation of superoxide anion is required for the normal production of most reactive oxygen and nitrogen species involved in oxidative stress [52].”
Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “ROS can be produced from endogenous sources, such as from mitochondria, peroxisomes, and inflammatory cell activation (Klaunig and Kamendulis 2004); and exogenous sources, including environmental agents, pharmaceuticals, and industrial chemicals.”
The Role of Resveratrol in Cancer Therapy (2017, background): “Tumor promoters generally alter gene expression, resulting in increased cell proliferation and decreased death of cells [76].”