Oxidative stress, DNA methylation and carcinogenesis.

By R. Franco, O. Schoneveld, A. Georgakilas, M. Panayiotidis. Cancer Letters, 2008

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Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. (2009, background): “Such DNA lesions can interfere with the binding of DNA methyltransferases to DNA, resulting in global hypomethylation (20).”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, neutral): “DNA Methylation [106]”
Crosstalk between mitochondria and NADPH oxidases (2011, background): “Production of ROS “in thewrong place at the wrong time” or generation of ROS in excessive amounts results in oxidative stress leading to cellular dysfunction and apoptosis, which contribute to atherosclerosis [11], heart failure [12], hypertension [13], ischemia/reperfusion injury [14], cancer [15],”
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements (2019, background): “It is thought that during the mitochondrial respiratory process, 1–2% of molecular oxygen is converted to ROS through one to three electron reductions and this leads to the formation of hydroxyl, hydrogen peroxide, superoxide, and peroxynitrite radicals [25].”