Sensing and repairing DNA double-strand breaks.

By Stephen P. Jackson. Carcinogenesis, 2002

1,205 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/4cb46a6369f21193a58886c4326731d5b537b70b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Bartek
2. Lei S. Qi
3. M. Löbrich
4. P. Jeggo
5. Luke A. Gilbert
6. Jonathan S. Weissman
7. Ines Krüger
8. L. Thompson

In Oncology

1. J. Bartek
2. P. Jeggo
3. Yosef Shiloh
4. M. Löbrich
5. M. O’Driscoll
6. A. Gorman
7. Thomas Helleday
8. Simone Fulda

In Public Health, Environmental and Occupational Health

1. M. O’Driscoll
2. Yosef Shiloh
3. P. Jeggo

Citations in the corpus

• Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle (2003, background): “This similarity provides further evidence that each -H2AX focus directly reflects the presence of a DSB. V3 cells complemented with a yeast artificial chromosome containing either the human (V3-147) (6) or the mouse (V3-155) (39) DNA-PKcs gene show a repair capacity similar to that of parental AA8 c”
• DNA damage and its links to neurodegeneration (2014, neutral): “When compared to other lesions, DNA DSBs are rare events; however, DSBs are also extremely deleterious because they can cause large chromosome rearrangements that can either lead to cell death, or promote tumorigenesis (Jackson, 2002).”
• Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014, background): “Additionally, double-stranded DNA breaks can be cytotoxic (Huang et al., 1996; Jackson, 2002).”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “The former constitutes the predominant DNA repair pathway in humans and involves DNA repair proteins such as DNA-PK, Ku70, and Ku80 [181, 182].”
• Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, neutral): “In mice, deficiency for any of the six known NHEJ pro-logs in yeast, while the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Artemis evolved more teins, similar to RAG deficiency, results in a SCID phenotype due to inability to join RAG-cleaved V, D, and Jrecently (Jackson, 2002).”
• The role of double-strand break repair — insights from human genetics (2006, background): “DSB response mechanisms DDR pathways encompass processes of DNA-repair and signal-transduction mechanisms that alert the cell to the presence of DNA damage and coordinate the appropriate respons”
• ATM and related protein kinases: safeguarding genome integrity (2003, background): “This is especially true for the response to highly cytotoxic DNA lesions, such as double-strand breaks (DSBs”
• The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair (2005, background): “S1 ) proficient in HRR but deficient in the non-homologous end joining pathway (NHEJ), an alternative but more error-prone mechanism of DSB repai”