Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

By K. Rothkamm, Ines Krüger, L. Thompson, M. Löbrich. Molecular and Cellular Biology, 2003

1,253 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/45091b1f7689201e2726100c65f008212e99ac29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. M. Foiani
5. G. Ira
6. Rodney Rothstein
7. J. Falck
8. Alan Ashworth

In Molecular Biology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. Thomas Helleday
5. Alan Ashworth
6. C. Lukas
7. M. Jasin
8. J. Haber

In Oncology

1. Stephen P. Jackson
2. J. Bartek
3. J. Lukas
4. M. Foiani
5. C. Lukas
6. J. Falck
7. J. Haber
8. Alan Ashworth

Citations in the corpus

• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “to the S/G2 phases of the cell cycle, whereas NHEJ is operational throughout the cell cycle (Rothkamm et al. 2003).”
• Repair of strand breaks by homologous recombination. (2013, background): “, meiotic DSBs into HR and immune system DSBs into NHEJ), DSBs from nucleases or radiation can be repaired by either HR or NHEJ pathways (Rouet et al. 1994b; Liang et al. 1998; Rothkamm et al. 2003).”
• The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “This pathway is mainly active during the S and G2 phases of the cell cycle following DNA replication, when a sister chromatid is available for use as a template for repair (Takata et al., 1998; Rothkamm et al., 2003).”
• Mechanisms of DNA damage, repair and mutagenesis (2017, positive): “Both of these E3 ligases ubiquitinate H2AX, which then serves as a docking site for 53BP1 and BRCA1.”
• DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 (2004, background): “Mammalian G1 cells predominantly repair ionizing radiation damage by NHE”
• DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “Most homologous recombination events occur between sister chromatids and should therefore be largely confined to the S and G2 phases of the cell cycle [89,90].”
• Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair (2010, background): “It has been previously shown that HR also preferentially repairs direct DSBs during late S/G2 phase (Rothkamm et al., 2003; Takata et al., 1998; Vispe et al., 1998), but this observation could be due to the fact that HR can repair DSBs only if two sister chromatids are present, which is more likely ”
• ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks (2006, background): “Third, whereas DSB repair by non-homologous end-joining (NHEJ; which does not require extensive ssDNA formation) can occur in all cell cycle stages, the contribution of homologous recombination to DSB repair increases as cells progress through the cell cycl”