The role of double-strand break repair — insights from human genetics

By M. O’Driscoll, P. Jeggo. Nature reviews genetics, 2006

611 citations recorded by the source corpus.

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/75f2390751714a5a916d45c9089c4820fd91f5b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. L. Naldini
2. L. Marácz
3. F. Grin
4. N. Pokorn

In Molecular Biology

1. Kenneth A Kim
2. M. Holmes
3. L. Naldini
4. L. Marácz
5. F. Urnov
6. Thomas Helleday
7. D. Ando
8. P. Gregory

Citations in the corpus

• Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery (2007, background): “A ZFN-induced ds break in the chromosome is repaired by nonhomologous end joining (NHEJ), an error-prone process that can lead to disruption of the targeted gene, or by homology-directed repair (HDR), a form of homologous recombination that faithfully copies the genetic information from a DNA molecu”
• Strategies to improve radiotherapy with targeted drugs (2011, background): “Deficiencies in pathways that repair DSBs, thought to be the most lethal lesion induced by ionizing radiation, such as non-homologous end joining (NHEJ) and homologous recombination (HR), are particularly detrimental to the cell”
• Chapter 1. General introduction (2015, positive): “Although checkpoint activation is not essential for DSB repair, it modulates how the damage is repaired and whether HR or NHEJ is used for repair (15).”
• DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “For example, DSBs caused by ionizing radiation result in a large fraction of DNA ends that contain additional DNA lesions at or close to the end, so-called ‘difficult’ DSBs [8].”