Phagocytes and oxidative stress.

By B. Babior. American Journal of Medicine, 2000

1,087 citations recorded by the source corpus.

Subfields: Immunology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/4c511c89cc2a702e09e2d605b00301cde64d50bd

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Citations in the corpus

Chronic inflammation and cancer. (2002, background): “However, they can also have detrimental effects, causing tissue damage and contributing to the development or progression of numerous diseases including cancer.[41] The same is true for reactive nitrogen intermediates, which are generated by inflammatory phagocytes through the enzymatic synthesis of”
Transient receptor potential cation channels in disease. (2007, background): “An involvement of ROS in the fight against invading pathogens has been postulated (28).”
Microglial Activation & Chronic Neurodegeneration (2010, background): “However, activation induces the cytosolic subunits to translocate to the membranes, where they bind to the membrane-associated subunits (p22 and gp91), assembling the active oxidase that produces O2 ● .(133) NADPH oxidase and intracellular ROS have been im-”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “In addition, myeloperoxidase catalyses the formation of hypochlorous acid (HOC1) in neutrophils, and a specific peroxidase catalyses the formation of hypobromous acid (HOBr) in eosinophils (Babior, 2000).”
Fluorescence probes used for detection of reactive oxygen species. (2005, background): “Endogenously produced ROS and RNS are essential to life, being involved in different biological functions, namely signal transduction, neurotransmission, smooth muscle relaxation, peristalsis, platelet aggregation, blood pressure modulation, immune system control, learning and memory, production of ”
Oxidation in rheumatoid arthritis (2004, background): “Phagocytic cells such as macrophages and neutrophils, on activation, undergo an oxidative burst that produces highly toxic ROS that are designed to kill the invading pathogens (reviewed in [1,2]).”
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “Microglia are a robust source of free radicals which can induce neuronal damage, and NADPH oxidase is implicated as both the primary source of microglial-derived extracellular ROS and a mechanism of pro-inflammatory signalling in microgli”
The macrophage foam cell as a target for therapeutic intervention (2002, background): “Macrophages express each of these enzymes, and in particular use MPO, iNOS and NADPH oxidases as means to generate antimicrobial reactive oxygen species essential for native immunit”
Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. (2005, background): “When the cell is activated, the cytosolic subunits (p47, p67, p40, and Rac2) migrate to the membranes, where they bind to the membrane-associated subunits (p22 and gp91) to assemble the active oxidase (Babior, 2000).”
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity (2002, background): “Many of them serve useful physiological functions,([1,2]) but they can damage the biomolecules when generated in excess, being implicated in the aetiology of several diseases and ageing.”
Inflammation as a causative factor in the aetiology of Parkinson's disease (2007, background): “is acted upon by stimuli such as bacterial toxins and some inflammatory peptides (Babior, 2000).”
Role of oxidative stress in Alzheimer's disease (2016, background): “Thus, the major enzymatic sources of O2• ̄ are NADPH oxidases located in various cell membranes, including polymorphonuclear, macrophages and endothelial cells (32-34), as well as cytochrome P450• ̄ and H2O2-dependent oxygenases (35,36).”
Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. (2012, background): “(Babior, 2000).”
Health effects of quercetin: from antioxidant to nutraceutical. (2008, background): “NADPH oxidase is dormant in resting phagocytic cells but comes into action when the cell is activated by invading micro-organisms (Babior, 2000).”