The macrophage foam cell as a target for therapeutic intervention

By Andrew C. Li, Christopher K. Glass. Nature Medicine, 2002

718 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/58ad836ff1f906d2aba2f996d8b232ea88c784e9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. TA Wynn
2. P. Murray
3. P. Calder
4. S. V. Van Dyken
5. R. Locksley
6. R. Medzhitov
7. Y. Okabe

In Immunology

1. TA Wynn
2. P. Murray
3. R. Locksley
4. S. V. Van Dyken
5. P. Calder
6. R. Medzhitov
7. A. Mantovani
8. Y. Okabe

In Surgery

1. P. Murray
2. TA Wynn
3. P. Calder

Citations in the corpus

• Innate and acquired immunity in atherogenesis (2002, background): “Components of oxLDL, in turn, can also activate macrophages and affect gene expression, such as expression of genes encoding peroxisome proliferator-activated receptor-γ, CD36 and ATP-binding cassette transporter A1, which profoundly influence macrophage inflammatory and atherogenic activity (discus”
• Oxidative Stress and Autophagy (2006, neutral): “With time, the macrophages are filled with loaded lysosomes, becoming “foam cells” with limited phagocytic activity (44).”
• Protective and pathogenic functions of macrophage subsets (2011, background): “, which stimulates the differentiation of highly activated macrophages, termed foam cells, that promote the formation of unstable lesion”
• The many faces of PPARgamma. (2005, neutral): “Attenuated lipid derivates like oxidized LDL are part of the pattern recognition code that triggers phagocytosis (Li and Glass, 2002).”