Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity

By L. Mira, M. Tereza Fernandez, Marta R. Santos, Rui M. Rocha, M. Helena Florêncio, K. Jennings. Free radical research, 2002

976 citations recorded by the source corpus.

Subfields: Biochemistry, Computational Theory and Mathematics, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/6fdf170fbe12ec38426c1bcadab88733a443022e

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Citations in the corpus

Response of Phenylpropanoid Pathway and the Role of Polyphenols in Plants under Abiotic Stress (2019, background): “Flavonoids can enhance the metal chelation process which helps in reducing the levels of harmful hydroxyl radical in plant cells [91,92] and this fits well with the observation that the levels of flavonoids in plants have found to be enhanced by metal excess [90,93].”
A review on the dietary flavonoid kaempferol. (2011, background): “Although flavonoids are known antioxidants, these compounds can also act as prooxidant agents under specific conditions [56].”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “, 2002) and Fe ions (Mira et al., 2002; Melidou et al., 2005) than the monohydroxylated kaempferol.”
Myricetin: A Dietary Molecule with Diverse Biological Activities (2016, background): “The reducing properties of myricetin towards Cu and Fe ions were attributed to the double bond at the C2-C3 position, the catechol in ring-B and the 3-hydroxy functional groups [63,64].”
Distribution and biological activities of the flavonoid luteolin. (2009, background): “The antioxidant activity of luteolin and its glycosides has been associated with their capacity to scavenge reactive oxygen and nitrogen species [41, 53-56], to chelate transition metals that may induce oxidative damage through the Fenton reaction [32, 57], to inhibit prooxidant enzymes [39, 58-60] ”
Beneficial effects of green tea: A literature review (2010, background): “Green tea catechins have the potential to affect absorption and metabolism of ions because flavonoids interact with a variety of metal ions [69].”
Kaempferol: A Key Emphasis to Its Anticancer Potential (2019, background): “At submicromolar concentrations, kaempferol is not only a potent scavenger of superoxide anion, hydroxyl radical, and peroxynitrite [32–34], but it also inhibits pro-oxidant enzymes, such as xanthine oxidase [35], and activates antioxidant enzymes suc as superoxide dismutase, catalase, and heme oxyg”
Concentrations of condensed tannins and anthocyanins in common bean seed coats (2010, background): “Previous studies have shown that flavonoids that complex iron to a higher degree are those possessing 30, 40 or 40-50-hydroxyl groups in the B-ring (Beninger & Hosfield, 2003; Mira et al., 2002).”
Variability of the phenolic profile in the diatom Phaeodactylum tricornutum growing under copper and iron stress (2013, background): “The main chemical process where polyphenols are involved is in the scavenging of reactive oxygen species (Neudorffer et al. 2006; Bentes et al. 2011), but phenolic compounds from plants can also act as antioxidants by chelating metal ions (Mira et al. 2002).”
Dietary polyphenols: good, bad, or indifferent for your health? (2007, background): “Many flavonoids chelate transition metal ions such as iron and copper, decreasing their ability to promote reactive species formation [46,51,52].”
Release of plant-borne flavonoids into the rhizosphere and their role in plant nutrition (2010, background): “Mira et al. (2002) showed that two flavones, myricetin and quercetin, interact strongly with Fe3+ with complexation occurring between the 5-hydroxyl and 4-oxo groups.”
Evidence for copper binding by extracellular root exudates of tall fescue but not perennial ryegrass infected withNeotyphodium spp. endophytes (2004, background): “This hypothesis is based on the fact that phenolic compounds can effectively chelate Cu (Brown et al., 1998; Mira et al., 2002; Suresh and Subramanyam, 1998).”
Jasmonic acid elicitation of Hypericum perforatum L. cell suspensions and effects on the production of phenylpropanoids and naphtodianthrones (2007, methodology): “Flavonoid spectra typically consist in two absorption maxima in the ranges 240–285 nm and 300–550 nm (Mira et al. 2002), while anthocyanins have two distinctive bands of absorption one in the UV region from 260 to 280 nm and another in the visible region from 490 to 550 nm (Giusti and Wrolstad,…”