Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches.

By S. Nilsson, Hayley M. Johnston, Judi A. Coverdale. Blood, 2001

603 citations recorded by the source corpus.

Subfields: Hematology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/4c06434305b970cf3336a14edc899c3c1d55f5dd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Linheng Li
2. T. Xie
3. S. Morrison
4. E. Laurenti
5. D. Lyden
6. Anne Wilson
7. A. Trumpp
8. P. Patterson

In Immunology and Allergy

1. Linheng Li

Citations in the corpus

• Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. (2002, background): “demonstrated that primitive, undifferentiated murine stem cells preferentially home to the endosteum region while the more differentiated progenitors do not [84].”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Typically, localization of HSCs in the BM is assayed by injecting purified, labeled HSCs into the circulation, followed by histological analysis of the BM around 15 hr later ( Nilsson et al., 2001; Wilson et al., 2004).”
• Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, methodology): “For quantitative localization of LS cells, enodosteal and central regions were defined as the zones within or outside twelve cells from the endosteum, respectively, as described previousl”
• The placenta is a niche for hematopoietic stem cells. (2004, background): “…self-renewal and differentiation of HSCs in specialized microenvironmental niches (Arai et al., 2004; Avecilla et al., 2004; Calvi et al., 2003; Nilsson et al., 2001; Tokoyoda et al., 2004; Zhang et al., 2003a), whereas embryonic hematopoiesis is compartmentalized into anatomical sites where…”
• HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, background): “These interactions mimic those observed between HSCs and the SDF-1–rich BM endosteum region in which hematopoietic progenitors are localized in close proximity to this chemokine (32, 36, 37), which is also a survival factor for both human and murine progenitors (38, 39).”
• Stem cell niche: structure and function. (2005, background): “In this section, we describe and compare the location and physical organization (if known) of adult stem cells in bone marrow, skin/hair follicle, intestine, neuron, and testis.”
• Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “However, visualization of stem cell niches in worms (Kimble and White, 1981), flies (Xie and Spradling, 1998), and eventually mammalian tissues (Doetsch et al., 1999; Nilsson et al., 2001; Quiñones-Hinojosa et al., 2006) has slowly illuminated our view of the niche and helped us determine how it can”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “In adults, hematopoiesis occurs in bone marrow in which hematopoietic stem cells (HSC) are primarily located in the osteoblastic niche on the bone surface (21, 22, 26, 27).”
• c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, methodology): “…due to a misregulated interaction with the local niche microenvironment. c-Myc-deficient HSCs home to the stem cell niche at the BM endosteum BM stem cell niches have recently been shown to be part of the endosteal lining of the internal bone cavities (Nilsson et al. 2001; Askenasy et al. 2002).”