Oxygen in stem cell biology: a critical component of the stem cell niche.

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Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “The low oxygen consumption of glycolytic metabolism appears well matched to the physiological hypoxia of the niche in which many different stem cells reside 340 Cell 163, 340–353, October 8, 2015 ª2015 The Authors (Burgess et al., 2014;Mohyeldin et al., 2010).”
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation (2012, neutral): “Stimulation of glycolysis in pluripotent stem cells, through hypoxia (Ezashi et al., 2005; Mohyeldin et al., 2010), inhibition of mitochondrial respiration (Varum et al., 2009), or supplementation with insulin (Chen et al., 2011), promotes stemness while inhibition of glycolysis halts proliferation…”
Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC (2011, background): “Hypoxic conditions therefore influence proliferation and cell fate commitment, meaning that gradients of oxygen tensions influence the prolonged maintenance of a stem cell phenotype and pluripotency [85].”
Loss of FBP1 by Snail-mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer (2013, neutral): “The induction of pluripotency with a glycolytic switch is consistent with the observation that a hypoxic environment maintains the stem cell state and hypoxia facilitates the reprogramming process (Mohyeldin et al., 2010).”