HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.

By O. Kollet, Shoham Shivtiel, Yuan-Qing Chen, Jenny Suriawinata, S. Thung, M. Dabeva, J. Kahn, Asaf Spiegel, Ayelet Dar, S. Samira and 8 more. Journal of Clinical Investigation, 2003

646 citations recorded by the source corpus.

Subfields: Hematology, Hepatology, Surgery

View Paper: https://www.semanticscholar.org/paper/546efd7c2fb208b07a5e610006f49310ed339cb6

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In Hematology

1. F. Balkwill
2. J. Talmadge
3. S. Fricker
4. B. Teicher
5. I. J. Fidler

Citations in the corpus

• The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities (2007, background): “The chemotactic factors identified here are particularly relevant for MSC homing and tissue repair, since tissue damage have been associated with local increase in mediators such as reported for SDF-1 or HGF [26, 46, 47].”
• Cancer and the chemokine network (2004, background): “Low CXCR4 levels could maintain stem cells in the systemic circulation, whereas increased CXCR4 levels would mediate attraction to other tissues in which CXCL12 levels are increased owing to tissue injury or infection, as well as homing back to the bone marrow and re-engraftmen”
• Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “12 ) and the proteolytic enzyme MMP-9, which are also involved in progenitor mobilizatio”
• Stem cell plasticity: time for a reappraisal? (2005, neutral): “HGF and stem cell factor, which are secreted after liver injury, increased the expression of CXCR4 and SDF-1 thus augmenting the recruitment of marrow cells to the liver.(56) This study underlines the potential of CD34 cells to migrate in response to stress signals in order to”
• The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “SDF-1 is upregulated in damaged tissues, such as the liver [9], arteries [10] or irradiated BM [11] (Table 1).”