Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
By F. Ishikawa, S. Yoshida, Yoriko Saito, A. Hijikata, H. Kitamura, Satoshi Tanaka, R. Nakamura, Toru Tanaka, H. Tomiyama, Noriyuki Saito and 10 more. Nature Biotechnology, 2007
978 citations recorded by the source corpus.
Subfields: Hematology, Immunology
View Paper: https://www.semanticscholar.org/paper/68567f1c1478b83371bc2412120e6a6f8245c243
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Citations in the corpus
- Evolution of the cancer stem cell model. (2014, background): “…resistance in glioblastoma, colon cancer, breast cancer, and numerous other tumors, where studies show that T-IC fractions are more resistant to therapy compared to non-T-IC (Bao et al., 2006; Diehn et al., 2009; Ishikawa et al., 2007; Saito et al., 2010; Viale et al., 2009; Zhang et al., 2010).”
- From carbohydrate leads to glycomimetic drugs (2009, background): “Once adherent to these microdomains in the bone marrow, leukaemic cells become quiescent and less susceptible to killing by anti-proliferative chemotherapy drugs such as cytosine arabinosid”
- CLONAL EVOLUTION IN CANCER (2012, background): “This may be because of the association with stromal cell”
- Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism (2017, background): “Surprisingly and as opposed to previous studies (9, 10), this cytoreduction was not associated with any consistent changes in stem cell functions, such as CD34+CD38− phenotype, G0 status, stem cell gene markers/ signature, or frequency of leukemia-initiating cells (LIC).”