Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

By A. Wagers, R. Sherwood, J. Christensen, Irving L. Weissman. Science, 2002

1,529 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/4b94ab490ac468f6375f9ea59e5d67126deef16b

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Citations in the corpus

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration (2003, background): “Whether Sca1 + cKit + Lin − cells have plasticity to transdifferentiate into various tissues, including ECs and SMCs, has been challenged in several studie”
Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. (2007, background): “Indeed, differentiation of stem cells into tissues different from their “natural” commitment is a rare phenomenon in healthy tissues (41), while it occurs in damaged tissues at widely varying rates of 0.”
A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. (2006, positive): “A single HSC can reconstitute the entire hematopoietic system of an irradiated mammal ( Wagers et al., 2002; Shizuru et al., 2005).”
A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential (2004, background): “However, this so-called “plasticity” appears to be an extremely rare event and may not carry a physiologically relevant impact in vivo (10).”
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, background): “Single murine HSC transplantation has resulted in detection of HSC-derived cells in the liver of irradiated recipients with a low percentage of transplanted cells exhibiting immunohistochemical and morphologic properties of hepatic epithelial cells (7), confirmed (as a rare event) in another report ”
Stem cell origin of cancer and differentiation therapy. (2004, background): “Is the ability of a bone marrow stem cell to contribute to an epithelial organ a very rare or a more common event? Krause and colleagues [57] find it to be a fairly common occurrence; whereas Wagers and colleagues [224] claim that this is an extremely rare event.”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, methodology): “Parabiotic mice Parabiosis surgery was performed as described elsewher”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “Injection into animal models also leads to varying tissue contributions, the degree of which may depend on previous cultivation steps, since freshly isolated HSCs do not seem to transdifferentiate with high efficiency (378).”
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes (2003, result): “These results suggest that previous observations of small numbers of Purkinje cells bearing markers of transplanted bone marrow cell”
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Very Low Cycling Activity of CD34LSKCD150CD48 Cells As ‘‘proof of principle’’ that mouse HSCs are bona fide adult stem cells, several investigators have succeeded in performing single-cell repopulation assays using BM subsets isolated by flow cytometry (Camargo et al., 2006; Dykstra et al., 2007; Wa”