Stem cell origin of cancer and differentiation therapy.

By S. Sell. Critical reviews in oncology/hematology, 2004

684 citations recorded by the source corpus.

Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/f3769b24c63c52d75dd7f214971e14bc0b196a58

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. Galli
2. B. Reynolds
3. Linheng Li
4. Angelo Luigi Vescovi
5. Yusuf A. Hannun
6. D. J. Barnes
7. W. Neaves
8. J. Melo

In Pediatrics, Perinatology and Child Health

1. B. Reynolds
2. Linheng Li
3. Angelo Luigi Vescovi
4. D. J. Barnes
5. W. Neaves
6. J. Melo

Citations in the corpus

• Chronic myeloid leukaemia as a model of disease evolution in human cancer (2007, background): “Differentiation arrest Abnormal or deficient differentiation is common in haematological malignancies and solid tumours with poor prognosi”
• Brain tumour stem cells (2006, background): “However, the 'no new neuron' dogma withstood the challenge: although resting embryonic-like tissue remnants, which can persist within the CNS parenchyma, were also envisioned as the possible cellular source of brain tumour”
• Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma (2006, neutral): “These fi ndings contrast with recent studies demonstrating that certain stem cell populations can promote or give rise to neoplastic growth (6, 28, 51).”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “have poorly differentiated phenotypes, two basic therapeutic approaches for combating cancers have developed: ‘‘differentiation therapy’’ (1) to induce differentiation and ‘‘destruction therapy’’ (2) to thwart malignant proliferation.”
• Substantial contribution of extrinsic risk factors to cancer development (2015, background): “5): (1) a total of m symmetric divisions before full tissue development, and (2) a total of a asymmetric divisions for normal tissue turnovers.”
• Tumour stem cells and drug resistance (2005, background): “Evidence for the existence of a pluripotent cell in solid tumours includes clinical observations with human TERATOCARCINOMAS , an experiment of nature in which differentiated tissues such as muscle and bone can appear in the tumour mas”