Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

By M. Álvarez-Dolado, R. Pardal, Jose Manuel García-Verdugo, J. Fike, Hyun O. Lee, K. Pfeffer, C. Lois, S. Morrison, Arturo Alvarez-Buylla. Nature, 2003

1,655 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a8c4cac5d62551647a254fe725e7eb3ed8859ee3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Z. Kokaia
2. O. Lindvall
3. U. Shivraj Sohur
4. Kenneth R. Boheler
5. B. Mitchell
6. J. Emsley
7. J. D. Macklis
8. A. Wobus

In Genetics

1. C. Hui
2. Kenneth R. Boheler
3. J. D. Macklis
4. A. Wobus
5. P. Labosky

In Molecular Biology

1. Stefanie Dimmeler
2. A. Zeiher
3. M. Schneider
4. C. Hui
5. Kenneth R. Boheler
6. J. D. Macklis
7. A. Wobus
8. P. Labosky

Citations in the corpus

• Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. (2004, background): “stem cell plasticity, including marrow stromal cells, raising questions about its mechanisms of transdifferentiation in vivo (27, 28).”
• A dermal niche for multipotent adult skin-derived precursor cells (2004, background): “Although some reported cases of multipotency are due to unanticipated cellular fusion event”
• The elusive nature and function of mesenchymal stem cells (2011, neutral): “Claims for in vivo differentiation into other cell types are equally controversial, as BM-derived mesenchymal stromal cell cultures have been shown to contribute to many tissues following transplantation through fusion with endogenous cells and not through differentiation into mature cell type”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “While the differentiation potential of some adult stem cells (hematopoietic and mesenchymal) are well-characterized in vivo (HSC) or in vitro (MSC), the transdifferentiation potential of most adult stem cells remains controversial (235, 378), partly as a consequence of culture conditions (175) and c”
• Unchain my heart: the scientific foundations of cardiac repair. (2005, methodology): “as a confounding factor (102), a pair of genetic tags was utilized: αMHC-Cre, the cardiomyocyte–specific expression of the DNA recombinase used widely for tissue-restricted knockout mutations, plus R26R, a ubiquitously transcribed but latent gene for β-gal (behind a Cre-deletable “stop” signal).”