Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury.

By F. Tögel, K. Weiss, Ying Yang, Zhuma Hu, Ping Zhang, C. Westenfelder. AJP - Renal Physiology, 2007

637 citations recorded by the source corpus.

Subfields: Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/5a9ae18343e6917e7a0f379ceaecf8fbad736856

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In Genetics

1. A. Caplan
2. D. Basile
3. T. Sutton
4. L. Meirelles
5. Melissa D. Anderson

In Surgery

1. A. Caplan

Citations in the corpus

• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “reported that infused MSCs attach to the renal microvascular circulation and decrease apoptosis of adjacent cells in a model of acute kidney injury [53].”
• Pathophysiology of Acute Kidney Injury (2012, positive): “For example, MSC produce high amounts of VEGF and IGFI, which when repressed via siRNA impair MSC effects on recovery from AKI (551).”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “kidney injury after MSCs infusion.(126) We reported that MSCs treated with TNFα and IFNγ could secret a large amount of VEGF-C that accelerates wound closure through promoting angiogenesis.”