Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

By Jun Wang, A. Ioan-Facsinay, Ellen I. H. van der Voort, T. Huizinga, R. Toes. European Journal of Immunology, 2007

1,123 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/48c37e7e958358a4ccc26ba7e1f2c961eb2761c1

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Citations in the corpus

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. (2017, background): “Although FOXP3 is themaster transcription factor for Treg differentiation and function, in human T cells, FOXP3 can also be transiently upregulated in conventional CD4+ T cells (Wang et al., 2007).”
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. (2012, background): “However, Foxp3 expression may not always specify Treg cells; in humans, activated T cells transiently upregulate FOXP3 without acquiring a Treg cell phenotype and function (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007; Ziegler, 2006), although such ‘‘promiscuous’’ Fox”
Foxp3 in control of the regulatory T cell lineage (2007, neutral): “As discussed above, this issue has been a subject of a continuous debate fueled by the data both supporting and against this possibilit”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, neutral): “, 2007) while others did not (Gavin et al., 2006; Wang et al., 2007; Allan et al., 2007).”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “…identify the genetic basis for the autoimmune disorder in human patients suffering from IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome and in the spontaneous mouse mutant scurfy (Bennett et al., 2001; Brunkow et al., 2001; Chatila et al., 2000; Wildin et al., 2001).”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “For example, it has been reported that mere TCR stimulation can induce FoxP3 expression in apparently naive human FoxP3 CD4 T cells without conferring suppressive activity (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007).”
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, background): “In human T cells, it is known that Foxp3 upregulation does not necessarily connote stable commitment to Treg differentiation (37, 38), so it is possible that not all of the newly derived Foxp3+ cells would go on to become Tregs.”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “This relatively low-level FOXP3 expression in activated human T cells requires TGF-β produced by activated T cells or present in serum, and it does not result in acquisition of Treg cell phenotype and suppressor activity (27, 191).”
Regulatory T Cells and Human Disease. (2020, background): “However, this expression is transient, at a low level, and does not confer significant in vitro suppressive activity (98).”