Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.

By Chunhong Zheng, Liangtao Zheng, Jae-Kwang Yoo, Huahu Guo, Yuanyuan Zhang, Xinyi Guo, Boxi Kang, Ruozhen Hu, Julie Y. Huang, Qiming Zhang and 6 more. Cell, 2017

1,827 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/40eac9ffeab24976b24e35003a070f734550fe7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Thommen
2. Ton N. Schumacher
3. Zemin Zhang
4. Yuanyuan Zhang
5. V. Karanikas

In Oncology

1. D. Thommen
2. Ton N. Schumacher
3. Zemin Zhang
4. Yuanyuan Zhang
5. V. Karanikas

Citations in the corpus

• Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. (2020, background): “21 these studies being focused on immune cell heterogeneity (31,45-51).”
• A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade (2018, background): “…determine whether predefined exhaustion gene sets showed enrichment in the PD-1T and PD-1N subsets (Crawford et al., 2014; Schietinger et al., 2016, Gupta et al., 2015, Quigley et al., 2010, Zheng et al., 2017, Doering et al., 2012, Baitsch et al., 2011, Tirosh et al., 2016, Singer et al., 2016).”
• Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020, background): “Natural killer (NK) and T cell clusters included CD4 and CD8 conventional and exhausted T cells, regulatory T cells (Treg), and naive-like T cells (Figure 1D), all bearing resemblance to subsets from prior solid tumor scRNA-seq studies (Guo et al., 2018; Puram et al., 2017; Savas et al., 2018; Tiros”
• T Cell Dysfunction in Cancer (2018, background): “The combined analysis of transcriptional profiles and TCR sequences of individual cells was recently used to investigate clonal relationships between distinct T cell clusters (Zheng et al., 2017).”
• The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications (2020, background): “This study is the first large-scale and in-depth analysis of TILs, revealing the underlying cellular mechanisms of HCC progression.(105) Collectively, these baseline analyses elucidated the basic properties of TILs in various cancer types.”
• GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis (2019, background): “Recently, single cell analyses based on the immune cells have gain tractions for different cancer types (14,19,20).”