CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.

By T. Malek, Aixin Yu, V. Vincek, P. Scibelli, Lin Kong. Immunity, 2002

897 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/481d528e57f51ce75b47af33521c9d9e2616b161

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In Immunology

1. T. Malek
2. S. Rosenberg
3. N. Restifo
4. E. Shevach
5. C. Piccirillo
6. Jian-Xin Lin
7. W. Liao
8. I. Castro

Citations in the corpus

• CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “Already known for its toxicity, another danger inherent in the administration of exogenous IL-2 may be the induction of Treg cell function (21, 44, 46, 55).”
• IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “Moreover, the adoptive transfer of wildtype CD4 CD25 cells into IL-2R - or IL-2R -deficient mice prevents development of lymphadenopathy and autoimmunity (25, 27).”
• A two-step process for thymic regulatory T cell development. (2008, background): “IL-2Rb (CD122)-deficient mice exhibit a decreased number of thymic Treg cells (Bayer et al., 2007; Burchill et al., 2007; Malek et al., 2002).”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “Relevant to this point, the severe lethal autoimmunity associated with IL-2Rb-deficient mice, which contain auto-aggressive T cells that cannot respond to IL-2 and IL-15, are ‘‘cured’’ from this disease by WT Treg cells (Malek et al., 2002).”
• IL-2, Regulatory T Cells, and Tolerance (2004, background): “It was later shown that mice deficient for the IL-2 or IL-2R genes lack CD4 CD25 T cells (36, 58, 59).”
• IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 (2007, background): “(4) established that the primary defect in IL2R -deficient mice was the loss of functional Tregs, as they found that transfer of small numbers of wild-type (WT) Tregs into neonatal IL-2R -deficient mice completely prevented the onset of autoimmune disease.”
• Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1 (2003, result): “These results extend a previous report that showed an essential role of IL-2 receptor in Treg homeostasis (14) suggesting further that costimulation through CD28 is critical in maintaining a high level of CD25 expression on Tregs.”
• Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function (2004, background): “mice, indicating that an intact IL-2/IL-2R pathway is required in the thymus for generation of CD4 CD25 cells (7).”