IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1

By S. Zheng, Juhua Wang, Pu Wang, J. Gray, D. Horwitz. Journal of Immunology, 2007

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Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? (2009, methodology): “Experiments utilizing IL-2 neutralization and IL-2-deficient T cells demonstrated that IL-2 is required in vitro for TGF-b induction of Foxp3 transcription and suppressor activity (Zheng et al., 2007).”
TGF-beta: a master of all T cell trades. (2008, positive): “TGF-β-induced iTreg cell differentiation was augmented by the T cell-produced cytokine IL-2 (Davidson et al., 2007; Zheng et al., 2007), which activates the transcription factor STAT5 for binding to the Foxp3 promoter (Burchill et al.”
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “In addition to thymic-derived natural Treg cells, naive peripheral CD4+ T cells can become CD4+FOXP3+-inducible Treg cells when stimulated with anti-CD3, TGF-b, and IL-2, with a critical role for IL-2 in their generation and expansion (Davidson et al., 2007; Zheng et al., 2007).”