CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

By P. Antony, C. Piccirillo, A. Akpinarli, S. Finkelstein, P. J. Speiss, D. Surman, D. Palmer, C. Chan, C. Klebanoff, W. Overwijk and 2 more. Journal of Immunology, 2005

792 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/0b2c8f9f6c33d26db608b42faa49aaa2015e3a03

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Citations in the corpus

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. (2005, background): “Cotransfer of CD4+CD25– helper cells, as a natural source of IL-2, may be helpful for the persistence and effectiveness of adoptive T cells (38).”
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma (2013, background): “…Intratumoral T reg cell depletion by –CTLA-4 | Simpson et al. JEM Vol. 210, No. 9 Article 1705 responses in a variety of malignancies (Antony et al., 2005; Chen et al., 2007; Li and Yee, 2008; Quezada et al., 2008; Klages et al., 2010), we predict that tumors containing…”
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts (2010, background): “Although the role of CD4+ Th cells in enhancing and sustaining CD8+ T cell responses is well established (Pardoll and Topalian, 1998; Antony et al., 2005), recent evidence suggests more direct roles, lending support to the use of tumor-reactive CD4+ T cells for cancer immunotherapy (Mumberg et al.”
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. (2007, background): “For example, adoptively transferred Treg cells can inhibit tumor-specific CD8 T cell-mediated immunity (Antony et al., 2005; Turk et al., 2004).”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “tumor elimination experimentally, the cotransfer of Tregs with CD8þ cells abrogates their efficacy in both ovarian cancer and melanomamodels (6, 18).”