Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1

By Q. Tang, K. Henriksen, E. Boden, A. J. Tooley, Jianqin Ye, S. Subudhi, Xincheng Zheng, T. Strom, J. Bluestone. Journal of Immunology, 2003

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Subfields: Immunology

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Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function (2004, background): “these defects appear to be independent of IL-2 (11).”
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 (2005, neutral): “Anti-CD28 (25) Recovery culture culture Culture”
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways (2008, background): “The development and peripheral survival of Tregs is CD28 dependent; thus, it is not surprising that blockade of the CD28 pathway using CTLA-4Ig in animal models of autoimmunity has resulted in a precipitous decrease in Tregs (139).”
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells (2009, background): “CD28 is a critical regulator of T reg cell homeostasis and function (Tang et al., 2003; Liang et al., 2005).”
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. (2006, background): “However, other studies have implicated CD28 in Treg survival and expansion (30, 31), complicating an interpretation of the role of CD28 in Foxp3 expression.”