IL-2, Regulatory T Cells, and Tolerance

By B. Nelson. Journal of Immunology, 2004

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CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “Lack of Treg cells, due to absence of IL-2 signaling, leads to uncontrolled CD4 T cell proliferation and activation, which paradoxically is not dependent on IL-2 (15, 21, 31, 51) However, even though IL-2 / mice get autoimmune disease, adoptive transfer of IL-2-deficient Th cells was unable to help ”
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1 (2005, background): “Percentage positive and MFI I 87 (179) 70 (60) 79 (256) 69 (52) II 89 (78) 79 (41) 84 (101) 47 (37) III 94 (66) 84 (44) 97 (76) 28 (45) IV 81 (45) 68 (39) 87 (56) 74 (28)”
IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “Moreover, the adoptive transfer of wildtype CD4 CD25 cells into IL-2R - or IL-2R -deficient mice prevents development of lymphadenopathy and autoimmunity (25, 27).”