Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals.

By Bruno Martin, K. Hirota, D. Cua, Brigitta Stockinger, M. Veldhoen. Immunity, 2009

818 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/46889a00edabc36367bbeed8aef1ff09d6e11aa5

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In Immunology

1. D. Artis
2. F. Powrie
3. C. Tato
4. D. Cua
5. M. Veldhoen
6. K. Maloy
7. M. V. D. van den Brink
8. A. Hanash

Citations in the corpus

• Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “In particular, γδ T cells can express the T H 17-associated transcription factors RORγt and the aryl hydrocarbon receptor (AHR), as well as the homing receptor CCR6, and can secrete IL-17 and IL-22 in response to IL-23 and IL-1&beta”
• Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22 (2011, background): “Similar to IL-22 expression in ILCs, IL-22 expression by γδ T cells can be driven by IL-1β, IL-23 and agonists of AhR, and IL-22 is coexpressed with IL-17A, IL-17F, IFN-γ or TN”
• Interleukin-22: immunobiology and pathology (2015, background): “be important for their IL-22 production, γδ T cells can also respond to innate ligands through Toll-like receptors (TLRs) (54, 58).”
• IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability (2015, neutral): “In general, distinct subsets of gd T cells exist and have unique function and homing capabilities, including the ability to produce either IL-17A or IFN-g in response to a variety of stimuli (Martin et al., 2009; Ribot et al., 2009).”
• γδ T cell effector functions: a blend of innate programming and acquired plasticity (2010, background): “In particular, interactions between extracellular bacteria and PRRs (such as TLR2 and dectin 1 (also known as CLEC7A)) expressed by mouse Vγ6Vδ1 + cells probably contribute to their early activation in intraperitoneal infection model”
• Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “AhR is also essential for the production of IL-22 by IL-17-producing gd T cells (Cibrian et al., 2016; Martin et al., 2009).”
• The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells (2011, background): “CCL20, a chemokine produced by IECs, controls the migra- tion of cells expressing CCR6, a homing receptor important for RORgt+ ILC migration to certain intestinal microenvironments (Cook et al., 2000; Tanaka et al., 1999).”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Dietary tryptophan, for instance, is processed to several different indole derivatives, which can act as ligands for the aryl hydrocarbon receptor (AhR) in host cells (Wikoff et al., 2009).”
• Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (2011, background): “We recently reported the induced expression of the transcription factor aryl hydrocarbon receptor (AhR) in differentiated TCRab+CD4+ T helper (Th) 17 cells (Veldhoen et al., 2008), which is mirrored in populations of CD44hiCCR6+ TCRgd T cells found in secondary lymphoid organs (Martin et al., 2009).”