Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

By Gregory F. Sonnenberg, L. Fouser, D. Artis. Nature Immunology, 2011

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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012, positive): “Chronic mucosal inflammation and tissue damage as seen in IBD predisposes patients to the development of colorectal cancer, one of the most frequent fatal cancers in the world.”
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (2015, background): “Although failure to produce IL-17 is an important aspect of the immunopathogenesis of HIES (5, 6), STAT3 also mediates signaling for another cytokine, IL-22, which is important for epithelial barrier function (11).”
Interleukin-22: immunobiology and pathology (2015, background): “There is extensive evidence that IL-22 mediates protection and regeneration of epithelial tissues in experimental models, including hepatitis, pancreatitis, colitis, and thymic injury (7, 138, 231, 232).”
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. (2012, background): “The importance of IL-22, acting via STAT3, in regulating the barrier function of epithelial cells and wound repair is a topic of considerable interest (Sonnenberg et al., 2011).”
Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “Acting on epithelial cells, IL-22 induces the release of antimicrobial peptides that protect the integrity of the mucosal barrier from pathogens (Ouyang et al., 2011; Sonnenberg et al., 2011).”