Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation.

By Y. Li, S. Innocentin, D. Withers, Natalie A. Roberts, Alec R. Gallagher, Elena F. Grigorieva, C. Wilhelm, M. Veldhoen. Cell, 2011

808 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/58269be339e2a96fd64fa20c9d3fea87e3c6184a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. Y. Belkaid

In Immunology

1. C. Garlanda
2. M. Colonna
3. A. Mantovani
4. S. Ghosh
5. M. Cella
6. Y. Belkaid
7. T. Postler
8. T. Hand

In Oncology

1. C. Garlanda
2. M. Colonna
3. S. Ghosh
4. Donald M Miller
5. A. Mantovani
6. Y. Belkaid
7. T. Hand
8. M. Karin

Citations in the corpus

• Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. (2013, neutral): “reuteri of human origin also produced IAld upon growing on Trp (data not shown), these findings imply that Trp supplementation in the context of antibiotic coverage might optimize antifungal and probiotic therapy and, most likely, immune physiology (Li et al., 2011).”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “Ligands for AhR, which may be derived from the activity of the microbiota (141), upregulate IL-22 and, to a lesser extent, IL-17 expression in Th17 cells (142).”
• Role of the Microbiota in Immunity and inflammation (2014, background): “In addition, dietary derived AHR ligands from cruciferous vegetables are important signals for intestinal immune development and immune responses (Kiss et al., 2011; Li et al., 2011).”
• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, neutral): “To study the AhR-dependent effects of the diet on the regulation of CNS inflammation by astrocytes we induced EAE in WT and GFAP AhR-deficient mice and, starting on day 22 we fed the mice a Trp-depleted diet (TDD) or TDD supplemented with Trp (TDD+Trp) as described 42 .”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “A few years later, four groups independently discovered that the AhR is in fact required for postnatal maintenance of IL-22-producing ILC3s, as well as the formation of isolated lymphoid follicles (Kiss et al., 2011; Lee et al., 2011; Li et al., 2011; Qiu et al., 2012).”
• The Effects of Vegetarian and Vegan Diets on Gut Microbiota (2019, background): “Through aryl-hydrocarbon receptors, the ligands act to promote intestinal immune function and gut homeostasis (95).”
• Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “2434 The gut microbiota, a complex community of >100 trillion microbes, plays an important physiological role in modulating host nutrition, metabolism, and immunity.(1,2)”
• Immune Dysfunction as a Cause and Consequence of Malnutrition (2016, background): “Development of novel experimental approaches to explore immune ontogeny [88,89], epigenetics [5,32–34], immunometabolomics [61], the gut microbiome [49] and virome [90], enteropathy [59], and nutrient-sensing [38,39] also provide unprecedented opportunities for translation into immunological studies”