Intestinal homeostasis and its breakdown in inflammatory bowel disease

By K. Maloy, F. Powrie. Nature, 2011

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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “An imbalance in this regulation results in inflammatory conditions of the gut including inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease (7, 8).”
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “Breakdown of these pathways – and the cytokine networks they are regulated by – can lead to IBD (Maloy and Powrie, 2011).”
Intestinal bacterial community structure differs between healthy and inflamed intestines in Atlantic salmon (Salmo salar L.) (2014, background): “, 2013) suggesting that SBM-induced enteritis resembles human chronic intestinal diseases such as inflammatory bowel diseases (IBD), which involve increased T cell-immune response and dysbiosis (Blumberg and Powrie, 2012; Chiodini et al., 2012; Maloy and Powrie, 2011).”
Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis (2014, neutral): “(H) Quantitative RT-PCR analysis of Csf2 expression in colonic NK cells (1), RORgt NCR ILC3 (2), RORgt NCR ILC3 (3), and RORgt LTi cells (4) isolated from Rorcmice.”