Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue

By A. Kiger, D. L. Jones, C. Schulz, M. Rogers, M. Fuller. Science, 2001

724 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/4576d11b68a313614e841d783dcd26c80d94f8e7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Morrison
2. M. Clarke
3. D. Scadden
4. James E. Darnell
5. T. Rando
6. M. Fuller
7. A. Spradling

In Molecular Biology

1. S. Morrison
2. Linheng Li
3. D. Scadden
4. M. Clarke
5. A. Spradling
6. T. Rando
7. Shenghui He
8. Daisuke Nakada

Citations in the corpus

• Stem cells, ageing and the quest for immortality (2006, background): “Studies of the importance of such changes in the stem-cell niche have been best described in the germline stem-cell niche in Drosophila”
• SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. (2003, background): “Cap cells (Xie and Spradling 1998, 2000) and somatic hub cells (Kiger et al. 2001; Tulina and Matunis 2001) in Drosophila, distal tip cells in Caenorhabditis elegans (Kimble and White 1981), and cells expressing the homeodomain transcription factor WUSCHEL in the Arabidopsis shoot apical meristem (M”
• Mechanisms of stem cell self-renewal. (2009, background): “Unpaired is required for the maintenance of spermatogonial stem cells, so the stem cells can be maintained only immediately adjacent to the hub (Kiger et al. 2001, Tulina & Matunis 2001).”
• The stem-cell niche as an entity of action (2006, background): “Within the Drosophila testis, Unpaired (UPD) is secreted by niche (hub) cells and induces stem-cell self-renewal via Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signallin”
• Stem cells and cancer: two faces of eve. (2006, background): “…niche, whereas the other daughter is displaced away from the Cell 124, M niche and activates expression of genes that launch this cell along the differentiation pathway (Chen and McKearin, 2003; Kiger et al., 2000, 2001; Tulina and Matunis, 2001; Xie and Spradling, 2000; Yamashita et al., 2003).”
• Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size (2005, background): “In this way, the Drosophila melanogaster germ cell niche both nurtures and constrains stem cells, maintaining strict control on stem cell number (1, 2).”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “For example, showing that GSCs are maintained at the gonad tips by local signals suggested the existence of a niche (Kiger et al., 2001; Tulina and Matunis, 2001; Xie and Spradling, 1998); but demonstrating that new stem cells can be introduced and maintained there provided the clearest evidence (Br”
• Signalling: STATs: transcriptional control and biological impact (2002, positive): “First, stem cells in the Drosophila testis require JAK–STAT signalling for self-renewal but not for differentiatio”