SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem.

By S. Sabatini, R. Heidstra, M. Wildwater, Ben Scheres. Genes & Development, 2003

729 citations recorded by the source corpus.

Stem cells self-renew and produce daughter cells that differentiate. How stem cells are specified and maintained is a central question in developmental biology. Plant stem cells occupy a small region or niche in larger zones of mitotic activity called meristems. Here we provide molecular evidence that in the Arabidopsis root meristem, the stem cell population depends on a central group of cells, the quiescent center (QC), which positions the stem cell niche. We show that the putative transcription factor SCARECROW (SCR), first identified by its role in radial patterning, is required cell-autonomously for distal specification of the QC, which in turn regulates stem cell fate of immediately surrounding cells.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/ee921ad258446c86b01ee5f73c2ab1df5d43aa85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Beeckman
2. Ben Scheres
3. R. Amasino
4. D. Beis
5. Malcolm J. Bennett
6. Doru C. Pamfil
7. J. Bowman
8. M. Aida

In Plant Science

1. T. Beeckman
2. Ben Scheres
3. R. Amasino
4. Martin Crespi
5. G. Berta
6. Claude Doussan
7. F. Merchan
8. A. Hodge

Citations in the corpus

• Control of Root Cap Formation by MicroRNA-Targeted Auxin Response Factors in Arabidopsisw⃞ (2005, background): “SHORT-ROOT and SCARECROW, two GRAS family putative transcription factors, play a role in both radial patterning and QC identity, and SCARECROW is required cell autonomously for QC specification (Di Laurenzio et al., 1996; Helariutta et al., 2000; Sabatini et al., 2003).”
• Plant root growth, architecture and function (2009, background): “The RAM constitutes the stem cell niche that eventually produces all below-ground organs, including lateral roots (Sabatini et al. 2003).”
• The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche. (2004, positive): “SHORT-ROOT College of Agricultural and Life Sciences (SHR) and SCARECROW (SCR), which encode members University of Wisconsin of the GRAS family of putative transcription factors, are Madison, Wisconsin 53706 required for QC identity in addition to their role in radial patterning (Di Laurenzio et al.”
• The Ancestral Developmental Tool Kit of Land Plants (2007, background): “…and SCARECROW (SCR), are required for radial patterning in both the root and the shoot (Benfey et al. 1993; Scheres et al. 1995; Di Laurenzio et al. 1996; Fukaki et al. 1998; Helariutta et al. 2000; Wysocka-Diller et al. 2000; Nakajima et al. 2001; Sabatini et al. 2003; Paquette and Benfey 2005).”
• Auxin Control in the Formation of Adventitious Roots (2011, positive): “Arabidospis SCR (AtSCR) is also involved in the establishment of quiescent center identity and in the maintenance of the stem cell status of the surrounding initial cells during embryonic pattern formation and postembryonal development (Sabatini et al., 2003), and its expression is associated with a”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “SHR and SCR proteins belong to the GRAS family of transcription factors and they direct the QC to maintain the proper functioning of the QC and SCN (Helariutta et al., 2000; Sabatini et al., 2003).”
• Auxin-dependent regulation of lateral root positioning in the basal meristem of Arabidopsis (2007, background): “…trap lines J0121, J0951, J1701, M0013 and Q1220 (http://www.plantsci.cam.ac.uk/Haseloff/ geneControl/catalogues/Jlines); the promoter trap QC184 (Sabatini et al., 2003); UAS:AUX1,aux1-22, J0951>>AUX1,aux1-22, UAS:axr3-1, J0121>>UAS:axr3-1 (Swarup et al., 2005), and pIAA14::mIAA14-GR lines…”