Notch signalling regulates stem cell numbers in vitro and in vivo

By A. Androutsellis‐Theotokis, R. Leker, F. Soldner, Daniel J. Hoeppner, R. Ravin, S. Poser, M. A. Rueger, S. Bae, Raja Kittappa, R. McKay. Nature, 2006

999 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/44fddd5024f5e8ca4e1a263f33ad8f0e04c3f14c

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In Molecular Biology

1. P. Dirks
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Citations in the corpus

• Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke (2009, methodology): “A previous study showed that infusion of a soluble Notch ligand promotes cell proliferation in the subventricular zone and migration of cells into the parenchym”
• Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. (2010, neutral): “, 2002), and supporting progenitor survival (Androutsellis-Theotokis et al., 2006).”
• RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “…pathways, which are essential for NSC maintenance, proliferation, and survival during development (Ohtsuka et al., 1999; Hitoshi et al., 2002; Androutsellis-Theotokis et al., 2006; Basak and Taylor, 2007; Mizutani et al., 2007) and control stem cell maintenance in several stem cell niches of…”
• The biology of cancer stem cells. (2007, background): “Notch signaling regulates neural stem cell expansion in vivo and in vitro (Androutsellis-Theotokis et al. 2006).”
• Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, background): “Mechanisms of neurogenesis in the fetal brain have been extensively studied, and pathways such as the wnt (67) and Notch (68,69) signaling cascades play an important role in this process.”
• MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, positive): “It has been reported that Notch signaling regulates stem cell numbers in vitro and in vivo [46].”
• Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition (2010, background): “, the critical signals mediating both EMT and stemnes”
• iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018, background): “The Notch signaling pathway promotes the self-renewal, differentiation, proliferation, survival, and migration of CSCs in several malignancies (20, 21).”
• Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “Notch signaling is also critical for normal hematopoiesis, breast development, colorectal epithelial maturation, immune regulation, and neural stem cell survival”