Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

By Muh-Hwa Yang, Dennis Shin-Shian Hsu, Hsei-Wei Wang, Hsiao‐Jung Wang, Hsin-Yi Lan, Wen-Hao Yang, Chi-Hung Huang, S. Kao, C. Tzeng, S. Tai and 3 more. Nature Cell Biology, 2010

671 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/393aaf35b4b1cc7052505a09c1eb3ec7332354f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Medici
2. Jormay Lim
3. David M. Gonzalez
4. J. P. Thiery
5. M. Nieto
6. Xiawei Wei
7. Weiqi Hong
8. Yuhe Huang

In Oncology

1. D. Medici
2. Jormay Lim
3. David M. Gonzalez
4. J. P. Thiery
5. M. Nieto
6. Xiawei Wei
7. Yuhe Huang
8. Weiqi Hong

Citations in the corpus

• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “However, direct evidence showing a pro-metastatic role for these myeloid cells through immunosuppression is lacking, even though CD11b+Gr1+ and CD11b+Ly6G+ cells promote metastatic processes (Yang et al., 2010; Casbon et al., 2015).”
• The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “Whether Twist belongs to one class or the other is still a matter of debate, as there is evidence for either an indirect action through Snail2 or direct repression when complexed with the polycomb-group protein BMI-1 (Casas et al. 2011, Yang et al. 2010).”
• Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “Similarly, in squamous cell carcinoma (SCC) TWIST is regulating BMI1 to cooperatively repress CDKN2A (p16 INK4A ) and promote tumor initiation capacities (Yang et al , 2010).”
• Epithelial-mesenchymal transitions: insights from development (2012, background): “Yang et al., 2010; Eckert et al., 2011 Srp and GATA Contains two GATA-type zinc fingers that bind to the consensus sequence AGATAG within regulatory regions.”
• The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “It directly binds the Bmi1 promoter and activates Bmi1, and hence TWIST1 can upregulate BMI1.”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Regulation of transcription is not mediated by Twist1 alone; however, BMI1, a polycomb-group repressor complex protein, acts in a concerted fashion with Twist to repress E-cadherin and the cell cycle inhibitor p16INK4α (42).”