Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.

By Sebastian Lugert, O. Basak, P. Knuckles, U. Haussler, K. Fabel, M. Götz, C. Haas, Gerd Kempermann, V. Taylor, C. Giachino. 2010

718 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Review these models are not mutually exclusive and may represent the coexistence of multiple neural stem cell types in the adult brain (Lugert et al., 2010).”
Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “NSC heterogeneity was recently proposed in a report describing a nonradial multipotent cell with astrocyte-like properties (Lugert et al., 2010).”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, methodology): “Subsequently, these mice have been utilized to determine that Notch signaling is active in Sox2-positive stem cells and inactivated in parallel with the initiation of NeuroD expression and the neuronal fate commitment in the SGZ (Ehm et al., 2010; Lugert et al., 2010).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “It appears that multi- ple types of NSCs, such as radial and nonradial precursors, coexist in the adult SGZ (Lugert et al., 2010).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript Table 1 Signals regulating adult hippocampal neurogenesis Stages Regulators Secreted factors and downstream effectors (Morphogens, growth fa”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, neutral): “Our results do not rule out the possibility that other cell types can behave as self-renewing and multipotent neural stem cells in the adult dentate gyrus under basal conditions and/or after stimulation, such as Sox2+ nonradial precursors (Lugert et al., 2010; Suh et al., 2007).”
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain (2019, background): “However, this microenvironment is still responsive to environmental changes and can be stimulated even at late stages to provide molecular cues for proliferation (van Praag et al., 2005; Kronenberg et al., 2006; Lugert et al., 2010; Silva-Vargas et al., 2013; Smith et al., 2018).”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “QNPs encompass the majority of neuron-producing stem cell activity in the adult DG and overlap to a large degree with other varieties of hippocampal stem cells which have been identified structurally, functionally, or by expression of other reporters (Eckenhoff and Rakic, 1984; Garcia et al., 2004; ”