Regulation of the Germinal Center Response by MicroRNA-155

By T. Thai, D. Calado, S. Casola, K. M. Ansel, Changchun Xiao, Yingzi Xue, A. Murphy, D. Frendewey, D. Valenzuela, J. Kutok and 5 more. Science, 2007

1,614 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3fc9ef6ebeecbf3cb64b205e11e437ce7f61c649

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Citations in the corpus

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. (2008, background): “Mice deficient in miR-155 showed defects in T cell– dependent antibody responses, whereby the functions of germinal center B cells, T helper cells, and dendritic cells were specifically impaired (18, 19 ).”
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. (2008, background): “…the functions of miRNAs during vertebrate development are only beginning to be explored, and there have been only a few reports of loss-of-function mutations of miRNAs in mice (Thai et al. 2007; van Rooij et al. 2007; C. Xiao et al. 2007; Zhao et al. 2007; Ventura et al. 2008; Wang et al. 2008).”
Differentiation of Effector CD4 T Cell Populations (2010, positive): “Indeed, miRNA-155-deficient T cells show a Th2 differentiation bias with increased IL-4 and decreased IFN-γ production possibly due to the increased expression of c-Maf, which is a direct target of miRNA-155 (276, 277).”
microRNAs and the immune response (2009, background): “Current Opinion in Pharmacology 2009, 9:514–520 the involvement of miR-155 in B-cell production of high affinity IgG1 antibodies, the development of B-cell memory and the production of cytokines such as TNFa and lymphotoxin-a/b [28 ,36].”
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. (2017, neutral): “Animal care and use The generation ofmiR-155KOmice has been previously described (Thai et al., 2007).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition to its function in monocytes, miR-155 was shown to have a physiological function in B and T cells (Thai et al., 2007). miR-155-deficient mice have a defect in the germinal center (GC) reaction and a concurrent weak T-cell-dependent antibody response.”
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. (2009, methodology): “cells (Rodriguez et al., 2007; Thai et al., 2007), but not in brain resident cells, we elaborated this point using mice expressing lacZ instead of miR-155 (Thai et al.”
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock1 (2007, background): “Two very recent reports showed that mice deficient for miR-155 are immunodeficient and that this miRNA is required for proper development of T, B, and dendritic cells (29, 30).”
Inflammation and cancer: An ancient link with novel potentials (2007, background): “deficient mice are immunodeficient and have a defective germinal center response.(96,97) IL-6 induces mir-let-7a and contributes to its”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “, was shown to be transcriptionally activated by the transcription factors activator protein 1 ( AP1 ) and nuclear factor-κB (NF-κB”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “For example, miR-150 impinges on B cell differentiation by targeting c-myb mRNA (Xiao et al., 2007), whereas miR-155 is required for T helper cell generation and germinal center activity (Rodriguez et al., 2007; Thai et al., 2007).”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “1) One of the viral latent transcripts in primary effusion lymophoma cells, miRNA-K12–11, has been found to target the same cellular microRNAs as miRNA-155, a cellular microRNA regulating the germinal centre reaction during B-cell maturation (Gottwein et al., 2007; Skalsky et al., 2007; Thai et al.,”
The Genetic Signatures of Noncoding RNAs (2009, background): “targets, give strong phenotypes [96–98], even though very few Name Characteristics Function Experimental Methodology References”