microRNAs and the immune response

By E. Tsitsiou, M. Lindsay. Current opinion in pharmacology (Print), 2009

701 citations recorded by the source corpus.

Although the immune response is predominantly controlled at the transcriptional level, microRNA-mediated RNA interference is emerging as an important regulatory mechanism that operates at the translation level. Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17–92 cluster, miR-150, miR-155, miR-181 and miR-223 have a ‘permissive’ function in the maturation, proliferation and differentiation of myeloid and lymphoid cells. Importantly, these actions of miRNAs often involve interactions with transcription factors. In contrast, the rapid and transient induction of miR-9, miR-146a and miR-155 has been speculated to negatively regulate the acute responses following activation of innate immune through down-regulation of proteins involved in the receptor-induced signalling pathways.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7bbe247cf31c7ef1782583f4b18381ca244ee4d9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Ke Zen
2. Isidore Rigoutsos
3. M. Boldin
4. K. Taganov
5. Elena Mogilyansky
6. David Baltimore
7. Ryan M. O’Connell
8. D. Rao

In Molecular Biology

1. Isidore Rigoutsos
2. M. Boldin
3. K. Taganov
4. Elena Mogilyansky

Citations in the corpus

• The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, positive): “Another study has shown that autoimmunity, characterized by increased proliferation and survival of CD4þ T cell, could be caused by overexpression of the miR-17/92 cluster in the DN1 stage.(88) Cardiovascular Diseases”
• Secreted monocytic miR-150 enhances targeted endothelial cell migration. (2010, background): “It has been reported that this monocytic miRNA was altered under various conditions, including the immune response (Tsitsiou and Lindsay, 2009) and several diseases (Amaral et al.”
• miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice (2011, background): “A growing body of evidence suggests that the development and function of cells in the immune system is particularly subject to regulation by miRNAs (Baltimore et al., 2008; Tsitsiou and Lindsay, 2009).”