Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.

By J. Stańczyk, D. L. Pedrioli, F. Brentano, O. Sánchez-Pernaute, C. Kolling, R. Gay, Michael Detmar, S. Gay, D. Kyburz. Arthritis & Rheumatism, 2008

910 citations recorded by the source corpus.

Subfields: Cancer Research, Rheumatology

View Paper: https://www.semanticscholar.org/paper/0ab968e37d1462f792f7e266e884705e0f69258a

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Citations in the corpus

miR-155 gene: a typical multifunctional microRNA. (2009, background): “In summary, miR-155 might function as a protective miRNA that locally down-regulates the expression of certain MMPs, thus controlling tissue damage due to inflammation [27].”
microRNA as Biomarkers and Diagnostics (2016, background): “Altered expression of miRNAs in the synovial tissue and synovial fibroblasts of patients with rheumatoid arthritis has been reported, and increased expression levels of miRNA miR-155 and miR-146a were found in rheumatoid arthritis (Stanczyk et al., 2008).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “It is predicted that miRNA account for 15% of the human genome and regulate at least 30% of protein-coding genes [4-8].”
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development (2010, background): “Elevated expression of miR-155 has been observed in brain lesions from multiple sclerosis (MS) patients (Junker et al., 2009) and in synovial samples from patients with rheumatoid arthritis (RA) (Stanczyk et al., 2008).”
The Role of MicroRNAs in Human Diseases (2010, background): “Specifically, increased miR-155 and miR-146a expression in RA synovial fibroblasts have been in comparison to those patients with Osteoarth-ritis (OA) (155) .”
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients (2008, background): “Stanczyk and coworkers [27] reported a fourfold increase in miR-146a expression and a twofold increase in miR-155 expression in RA synovial fibroblasts compared with osteoarthritis synovial fibroblasts.”