A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

By Peggy Lee, D. Fitzpatrick, C. Beard, H. Jessup, S. Lehar, K. Makar, M. Pérez-Melgosa, M. Sweetser, Mark Schlissel, Suzanne Nguyen and 7 more. Immunity, 2001

1,285 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3fa1d69a935316d6c9cbef2d9afa797a4daecf7a

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Citations in the corpus

• Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages (2008, methodology): “Stat3f/f mice (Takeda et al., 1999) were bred with CD4-Cre mice provided by C. Wilson (Lee et al., 2001).”
• T cell lipid peroxidation induces ferroptosis and prevents immunity to infection (2015, positive): “TGpx4/Gpx4 and tamGpx4/Gpx4 mice were generated by crossing Gpx4fl/fl mice (C57BL/6; n > 8; Seiler et al., 2008) to Cd4-cre (JAX; Lee et al., 2001) and Ert2-Cre (Hameyer et al., 2007), respectively.”
• A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration (2005, methodology): “T-cell ablation in CD4-Cre/iDTR mice by application of DT To investigate the functional properties of the iDTR system in vivo , we crossed iDTR mice to CD4-Cre mic”
• Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses (2004, background): “Deletion of Gata3 in activated CD4 + T cells in vivo We crossed Gata3 fl/fl mice to CD4-Cre transgenic mic”
• Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, background): “To examine the effect of STIM deficiency in T cells, we crossed mice with lox P-flanked Stim1 ( Stim1 fl/fl ) or Stim2 ( Stim2 fl/fl ) with mice expressing a Cre transgene under control of a Cd4 enhancer-promoter-silencer cassette (CD4-Cre) that causes deletion at the double-positive (CD4”
• IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 (2007, methodology): “We crossed these animals to CD4-Cre transgenic mice in which Cre protein is expressed in CD4 CD8 and CD4 thymocytes, as well as in peripheral CD4 T cells (29).”
• Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1 (2003, methodology): “To restrict deletion of the Mcl-1 f allele to T-cell development, we introduced the lymphocyte-specific protein tyrosine kinase–Cre (Lck–Cre) transgen”
• Epigenetic control of T-helper-cell differentiation (2009, background): “Genetic evidence supported these findings: conditional ablation of DNMT1 or MBD2 — which recruit HDACs and chromatin-remodelling complexes to methylated DNA and induce a repressive chromatin state — led to increased expression of IFNγ and T H 2-type cytokines and an inability of T H 1 or T H 2 cells”
• Deletion of β-catenin impairs T cell development (2003, background): “with mice expressing the Cre transgene under the control of the proximal Lck promote”
• Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. (2008, background): “Mice with Smad4 deletion in T cells were generated by breeding mice with floxed Smad4 (fl) alleles (Chu et al., 2004) with CD4-Cre mice (Lee et al., 2001).”