Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

By Jinfang Zhu, B. Min, J. Hu‐Li, C. Watson, A. Grinberg, Qi Wang, N. Killeen, J. Urban, Liying Guo, W. E. Paul. Nature Immunology, 2004

708 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/880819e426339daf8d3298541084991866567644

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In Immunology

1. W. E. Paul
2. Jinfang Zhu
3. H. Yamane
4. M. Saraiva
5. C. Mauri
6. A. O’Garra
7. J. Allen
8. Rick M. Maizels

Citations in the corpus

• Diversity and dialogue in immunity to helminths (2011, background): “or the transcription factor GATA-binding protein 3 (GATA3”
• CD4+T Cells: Differentiation and Functions (2012, background): “Absence of GATA3 leads to the interruption of Th2 differentiation [37, 39, 40].”
• CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation (2013, methodology): “For TH1 conditions, recombinant human IL-12 (rhIL-12) (10 ng/ml) (Miltenyi Biotec) and anti–IL-4 (10 mg/ml) (PeproTech) were added to the culture as indicated (49).”
• Differentiation of Effector CD4 T Cell Populations (2010, positive): “Deleting Gata3 from Th2 cells allows the production of IFN-γ (57); reduction of Foxp3 in Tregs renders them able to gain a Th2 phenotype (84); Gfi1 deletion from Th2 cells results in active epigenetic modifications at Th17- and iTreg-related gene loci, including Rorc, Il23r, and Cd103 (160).”
• Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset (2008, background): “Loss of GATA-3 by conditional gene deletion in an established T H 2 population has been shown to abolish the production of IL-5 and IL-13 but not IL-4 productio”
• Epigenetic control of T-helper-cell differentiation (2009, background): “In addition to silencing Ifng , GATA3 is essential for promoting the expression of T H 2-type cytokines and consequently for inducing and, at least partly, maintaining the T H 2-cell respons”
• The regulation of IL-10 production by immune cells (2010, background): “In T H 2 cells, IL-10 production seems to be regulated by the main T H 2 type-associated signalling pathways and transcription factors: IL-4, STAT6 and GATA binding protein 3 (GATA3”
• Zinc as a Gatekeeper of Immune Function (2017, background): “Moreover, GATA-3 is essential for Th1 and Th2 subpopulation differentiation [226,227].”
• How are TH2-type immune responses initiated and amplified? (2010, background): “Although the concentration of GATA3 remains low in such cultures, GATA3 is still essential for T H 2 cell differentiation, as constitutively active STAT5A fails to induce T H 2 cells differentiation in the absence of Gata3 (Ref”
• The transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells (2012, positive): “This is another striking parallel to the role of GATA-3 in Th2 cells, as they also require continuous GATA-3 expression for their maintenance (Pai et al., 2003; Zhu et al., 2004).”
• Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “Indeed, sequential exposure of both mouse and human CD4 T cells to IL-4 and IL-12 results in IL4 ⁄ IFNc double-producing cells in vitro (45, 46).”