A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration

By T. Buch, Frank Heppner, Christine Tertilt, T. Heinen, M. Kremer, F. Wunderlich, Steffen Jung, A. Waisman. Nature Methods, 2005

847 citations recorded by the source corpus.

Subfields: Biotechnology, Immunology

View Paper: https://www.semanticscholar.org/paper/d72e4626eabfdcf0060bf0c4331bb7772c2c9a0f

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In Immunology

Citations in the corpus

The use of animal models in diabetes research (2012, background): “insulin producing cells as mouse cells do not normally express the DT receptor, and thus, other cells are not susceptible to damage (Buch et al., 2005).”
Leptin Receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow (2014, neutral): “, 2001), Rosa26-loxp-stop-loxp-iDTR (Buch et al., 2005), NG2-creER (Zhu et al.”
Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration (2012, neutral): “Cg-Gt(ROSA) 26Sortm9(CAG-tdTomato)Hze/J), Rosa26-loxP-stop-loxP-DTR (iDTR) (Buch et al., 2005), and Rosa26-loxP-mTomato-loxP-mEGFP (mTmG, B6.”
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011, neutral): “2-adrenergic receptordeficient (Adrb2tm1Bkk/J; Chruscinski et al., 1999; gift from G. Karsenty, Columbia University, New York, NY), 3-adrenergic receptor-deficient (FVB/N-Adrb3tm1lowl/J; Susulic et al., 1995; The Jackson Laboratory), FVB/ N-CD11b-DTR (Cailhier et al., 2005; gift from C. Aloman, Moun”
Differential Roles of Macrophages in Diverse Phases of Skin Repair (2010, methodology): “To generate mice in which macrophages can be depleted in a temporally controlled manner, we bred the inducible diphteria toxin receptor (iDTR) mice (C57BL/6 background) (20) with mice expressing the Cre recombinase (C57BL/6 background) from the myeloid cell-specific lysozyme M promoter (LysMCre) [pr”
Microglia promote learning-dependent synapse formation through BDNF (2013, methodology): “To accomplish this, CX3CR1 CreER mice were crossed with mice harboring the Rosa26-stop-DTR (R26) allele (Buch et al., 2005), and CX3CR1 :R26 mice were given tamoxifen 30 days”
Dynamics Between Stem Cells, Niche and Progeny in the Hair Follicle (2011, positive): “K15-CrePGR mice were used to induce expression of Diphtheria Toxin Receptors (DTRs) (Buch et al., 2005) in CD34+ bulge cells.”
Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart (2014, methodology): “Mouse strains used included Mlc2v-Cre, Rosa26-DTR, Rosa26-td, Flt3-Cre, CSF1R-MerCre, and CCR2 (9, 16, 17, 19, 23, 24).”
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, methodology): “That treatment regimen was based on an study showing that a 7-day injection regimen is required for efficient elimination of CD4 + T cell”