ICOS co-stimulatory receptor is essential for T-cell activation and function

By C. Dong, A. Juedes, U. Temann, S. Shresta, James P. Allison, N. Ruddle, R. Flavell. Nature, 2001

1,029 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3610e578762b28e30ba9678b47589cba727e306b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “ICOS-deficient humans and mice (Dong et al., 2001; McAdam et al., 2001; Tafuri et al., 2001) and ICOS-L-deficient mice have marked deficits in antibody production, isotype switch, and GC formation.”
Costimulatory molecule ICOS plays a critical role in the development of TH-17 and follicular T-helper cells by regulating c-Maf expression and IL-21 production (2008, background): “Both ICOS-deficient and ICOS-L-deficient mice have defects in humoral immunity characterized by less immunoglobulin E and G1 in the serum and defects in antibody class switching and germinal center formatio”
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. (2008, background): “We previously found ICOS-c-Maf pathway only controls IL-4 but not IL-5 or IL-10 expression in effector TH2 cells and ICOS deficiency selectively abrogates IL-4dependent IgE production but not IL-5-mediated airway eosinophilia (Dong et al., 2001; Nurieva et al., 2003).”
Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity (2002, background): “Moreover, ICOS −/− mice seem to be prone to the development of experimental allergic encephalomyeliti”
Asthma: an epidemic of dysregulated immunity (2002, background): “and ICOS −/− mice appear to be prone to the development of experimental allergic encephalomyeliti”
BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas (2005, background): “ICOS-ICOSL signalling is important in T cell activation, proliferation and cytokine production [33,34].”
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005, methodology): “For the induction of EAE, mice were immunized with the MOG peptide (amino acids 35–55; MEVGWYRSPFS ROVHLYRNGK) emulsified in CFA as describe”
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency (2003, background): “This concept proved correct with the establishment of a murine model in which the genomic deletion of Icos led to a disturbance of the humoral immune syste”