Asthma: an epidemic of dysregulated immunity

By D. Umetsu, J. McIntire, O. Akbari, C. Macaubas, R. DeKruyff. Nature Immunology, 2002

658 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Physiology

View Paper: https://www.semanticscholar.org/paper/935fbe9020034251f6c1af3bfb7afb20a3f6e698

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. O’Shea
2. H. Hammad
3. B. Lambrecht
4. Rick M. Maizels
5. A. Balic
6. M. Wilson
7. Matthew D Taylor
8. J. Lamb

In Infectious Diseases

1. S. Mazmanian
2. M. Wilson
3. Y. Belkaid
4. June L. Round
5. Yan Wang
6. L. Kasper
7. O. Harrison
8. Jeffrey I. Gordon

In Physiology

1. H. Hammad
2. B. Lambrecht
3. Rick M. Maizels
4. M. Wilson
5. S. Mazmanian

Citations in the corpus

• Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. (2007, background): “For instance, Th1 cells have been thought to contribute to pathology in Crohn’s disease (Strober et al., 1998), whereas Th2 cells have been implicated in asthma (Umetsu et al., 2002).”
• Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, positive): “Current theories postulate that pathogen-induced T reg cells control both Th1 and Th2 effector populations (2, 3, 11, 16, 27, 53).”
• Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen (2004, background): “In support of this theory, DCs obtained from lung draining LNs of tolerized mice were able to induce T cell unresponsiveness ex vivo and transfer tolerance to naive mice, in a process that required active T cell costimulation through either CD86 or ICOS-L (3, 5, 21).”
• An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. (2005, background): “The “hygiene hypothesis” suggests that the appropriate bacterial constitution of the human microflora is a factor in protection from allergy and asthma (Umetsu et al., 2002; Von Hertzen and Haahtela, 2004).”
• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice (2005, neutral): “dtd" [ ]> Asthma is a disease of dysregulated immunity characterized by chronic inflammation in the airways in response to a wide variety of stimuli, including airborne allergens, infectious agents, chemical irritants and other”