Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

By O. Akbari, G. Freeman, E. Meyer, E. Greenfield, Tammy T. Chang, Arlene H. Sharpe, Gerald J. Berry, R. DeKruyff, D. Umetsu. Nature Medicine, 2002

871 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/b55270ede34d5ca0552ae837d80f9ba492df3b92

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. H. Hammad
2. B. Lambrecht
3. M. Saraiva
4. A. O’Garra
5. F. Quintana
6. Howard L. Weiner
7. M. Battaglia
8. D. Umetsu

In Physiology

1. H. Hammad
2. B. Lambrecht
3. F. Quintana

Citations in the corpus

• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “Experiments in which naive OVA-specific T-cell receptor (TCR)-transgenic T cells were adoptively transferred before antigen inhalation showed that the induction of tolerance is accompanied by the vigorous proliferation of naive T cells even when low doses of the antigen are given, implying that at l”
• Mechanisms of Cisplatin Nephrotoxicity (2010, background): “tolerance by various mechanisms including production of TGF-β [191] or IL-10 [192] and induction of Treg cells via the ICOS-ICOS-ligand pathway [193].”
• Oral tolerance (2011, background): “were also reported for DCs isolated from the bronchial mucosa, which preferentially induced IL-10 responses whereas those from the gut induced TGF-b responses (21, 22).”
• Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “OVA in vitro High IL-10 IBD (14, 86) OVA in vitro Vit D3+ Dexa EAE (23) OVA in vitro CD45RB DC IBD (146) OVA in vivo OVA intranasally Airway inflammation (18, 19) OVA in vivo CD8a+ DC Airway inflammation (240)”
• Asthma: an epidemic of dysregulated immunity (2002, background): “Allergen-specific CD4 + regulatory T (T R ) cells mediate, in part, the T cell tolerance that inhibits airway inflammation and AH”
• The regulation of IL-10 production by immune cells (2010, background): “Signals delivered through inducible T cell co-stimulator (ICOS) have also been suggested to induce IL-10 expression by FOXP3 − regulatory T cell”