Discovery of Atg5/Atg7-independent alternative macroautophagy

By Y. Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, T. Kanaseki, M. Komatsu, K. Otsu, Y. Tsujimoto, S. Shimizu. Nature, 2009

1,039 citations recorded by the source corpus.

Subfields: Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/3563598fbc72803cb646c7886e73ca22648031a7

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Citations in the corpus

mTOR regulation of autophagy (2010, background): “one dependent and the other independent upon Atg5/Atg7 [93].”
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells (2011, background): “Alternatively, this small amount of LC3-II could be due to ATG7-independent autophagy, as described (22).”
Measuring in vivo mitophagy (2015, background): “Similarly, the removal of mitochondria can apparently proceed in the absence of the conventional macroautophagy machinery as observed during the process of reticulocyte maturation (Honda et al., 2014; Zhang et al., 2009), or when cells are exposed to certain specific stresses (Nishida et al., 2009).”
Autophagy gone awry in neurodegenerative diseases (2010, neutral): “99 ) and autophagosome formation even in the absence of Atg5 and Atg7 (ref”
Recent insights into the function of autophagy in cancer (2016, background): “The concern with this conclusion is that noncanonical autophagy programs such as Rab9-associated (Nishida et al. 2009) or TRIM31-associated vesicles (Ra et al. 2016) can be recruited in cells deficient in canonical autophagy genes.”
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control (2014, methodology): “…observe a change in the ratios of PDH E2/E3 bp-positive/TOM20-negative puncta (vesicles) with those that were doubly-positive (mitochondrial fragments) that colocalized with GFP-parkin (Supplementary Fig S4C), as would be expected if parkin were degrading TOM20 from the surface of these structures.”
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “Furthermore, recent studies have identified an unconventional, mTOR-independent form of autophagy that further complicates the link between these pathways (Nishida et al., 2009).”
The Beclin 1 network regulates autophagy and apoptosis (2011, positive): “Furthermore, recent study has identified a Atg5/Atg7independent pathway of autophagy.(3) This pathway of autophagy was not associated with LC3 processing but appeared to involve autophagosome formation from late endosomes and the trans-Golgi.”
Autophagy in mammalian development and differentiation (2010, background): “Thus, upstream factors may show more severe phenotypes, or alternatively, as recently reported, downstream factors may be dispensable for a particular type of macroautophag”
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. (2010, background): “Recently, it has been shown that autophagy can occur through an Atg5/Atg7-independent alternative pathway (19).”
Nix is a selective autophagy receptor for mitochondrial clearance (2010, background): “As, however, ATG5/ATG7-independent autophagy has now been described, more studies are required to understand the role of autophagy in reticulocyte maturation”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “For example, in response to cytotoxic stress (treatment with etoposide), autophagosomes are formed in an ATG5- and ATG7-independent manner (see Noncanonical use of autophagy-related proteins).(27) While this does not rule out involvement of other macroautophagy regulators/components in the formation”