Nix is a selective autophagy receptor for mitochondrial clearance

By I. Novak, V. Kirkin, David G. McEwan, Ji Zhang, P. Wild, Alexis Rozenknop, V. Rogov, F. Löhr, Doris Popovic, A. Occhipinti and 5 more. EMBO Reports, 2010

1,282 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7b5747f4364bbc2cf478cac15e870974b96b82b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. I. Slaninová
3. N. Mizushima
4. Beth Levine
5. Guido Kroemer
6. V. Deretic
7. Alec C. Kimmelman
8. E. White

In Epidemiology

1. Beth Levine
2. N. Mizushima
3. D. Klionsky
4. I. Slaninová
5. Guido Kroemer
6. Alec C. Kimmelman
7. V. Deretic
8. E. White

In Molecular Biology

1. Beth Levine
2. Guido Kroemer
3. I. Slaninová
4. N. Mizushima
5. D. Klionsky
6. R. Youle
7. Alec C. Kimmelman
8. V. Deretic

Citations in the corpus

• Mechanisms of Selective Autophagy (2016, positive): “However, some non-canonical LIR motifs, which do not apparently match this consensus, are also found [30,84,85].”
• Autophagy and the integrated stress response (2010, positive): “, 2009) as well as BNIP3L (also known as NIX), which binds to mitochondrial membranes (Novak et al., 2010).”
• Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells (2012, methodology): “(c) HeLa cells were transfected with (Flag)N-Fundc1(1-155)-C(Myc) or (Flag)N-Fundc1(1-139)C(Myc) vectors, respectively.”
• Autophagy in mammalian development and differentiation (2010, background): “Nix is required for the selective removal of mitochondria but not that of ribosomes or nuclei; in Nix −/− reticulocytes, autophagosomes are generated but there is a deficiency in the loss of the mitochondrial membrane potential and consequent mitochondrial engulfment by autophagosome”
• Mechanisms of mitophagy (2011, background): “NIX is localized to the OMM and contains a WXXL-like motif facing the cytosol, which binds the mammalian Atg8 orthologue, LC3, and the LC3 homologue, GABA receptor-associated protein (GABARAP), in vitro and in vivo”
• Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “Certain types of mitophagy induced by BNIP3L/NIX are highly dependent on GABARAP and less dependent on LC3 proteins.(147) Furthermore, commercial antibodies for GABARAPL1 also recognize GABARAP,(108) which might lead to misinterpretation of experiments, in particular those using immunohistochemical ”