Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
By B. Hartleben, Markus Gödel, C. Meyer-Schwesinger, Shuya Liu, T. Ulrich, Sven Köbler, T. Wiech, F. Grahammer, S. Arnold, M. Lindenmeyer and 7 more. Journal of Clinical Investigation, 2010
697 citations recorded by the source corpus.
Subfields: Epidemiology, Nephrology
View Paper: https://www.semanticscholar.org/paper/40426051aff8c1f57ad3e27bec7f589cbcaae8a5
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In Epidemiology
- Beth Levine
- N. Mizushima
- M. Komatsu
- D. Klionsky
- Alec C. Kimmelman
- Guido Kroemer
- I. Slaninová
- V. Deretic
Citations in the corpus
- Molecular mechanisms of diabetic kidney disease. (2014, neutral): “Podocytes have one of the highest autophagy levels in the body (82).”
- Autophagy in mammalian development and differentiation (2010, background): “Subsequently, autophagy was shown to be essential for the delivery of certain endogenously synthesized antigens to MHC II loading compartment”
- Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene (2010, background): “With respect to kidney disease risk, apolipoprotein L-1 is also prominently involved in autophagic pathways (Zhaorigetu et al. 2008), and a recent study has provided compelling evidence for the role of well-preserved autophagy in the integrity of renal glomerular podocytes (Hartleben et al. 2010).”
- Autophagy: Renovation of Cells and Tissues (2011, background): “In addition, these mice show increased susceptibility to proteinuric renal diseases caused by puromycin aminonucleoside and adriamycin, which normally upregulate autophagic activity in intact podocytes (Hartleben et al., 2010).”