Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

By Jennifer Martinez, Johann Almendinger, A. Oberst, Rachel A. Ness, C. Dillon, Patrick Fitzgerald, Michael O. Hengartner, Douglas R. Green. Proceedings of the National Academy of Sciences of the United States of America, 2011

650 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/487cdba00361e1a65ccfef429ee530c3abb526da

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Citations in the corpus

Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “Sequestration inhibitors, including 3-MA, LY294002 and wortmannin, inhibit class I as well as class III PtdIns3Ks.134,257,707 The class I enzymes generate products [PtdIns(3,4,5)P3] that inhibit autophagic sequestration, whereas the class III product (PtdIns3P) generally stimulates autophagic seques”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “LC3-associated phagocytosis (LAP) is required for the clearance of dead cells (186).”
Ferroptosis in infection, inflammation, and immunity (2021, background): “Clearing these dead cell corpses without destroying healthy neighboring cells through phagocytosis (within tissues) or shedding (from epithelial surfaces) plays a vital role in sustaining cell homeostasis (Boada-Romero et al., 2020; Doran et al., 2020; Martinez et al., 2011; Qu et al., 2007).”
To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “If LAP is defective (due, for example, to lack of the requisite autophagy machinery), the corpse is not digested, and macrophages produce high levels of proinflammatory cytokines (Martinez et al., 2011).”
Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis (2012, background): “The finding of double membranes in our cell culture model indicates that autophagy is occurring, but it is theoretically possible that an additional single-membrane process involving LC3-II, ATG5, and Beclin1, such as LC3-associated phagocytosis (LAP) (Martinez et al., 2011; Florey et al., 2011), is”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “PtdIns3P can also be seen at LAP-engaged phagosomes minutes after phagocytosis.(180,182,1449) (b) EM analysis reveals that LAP involves single-membrane structures.”
Cell Death Signaling. (2015, background): “Recent studies have shown that components of the autophagy pathway can be recruited to phagosomes that have engulfed organisms or cells, facilitating the degradation of the phagocytosed cargo (Sanjuan et al. 2007; Martinez et al. 2011).”