A Simple Cipher Governs DNA Recognition by TAL Effectors

By M. Moscou, Adam J. Bogdanove. Science, 2009

1,976 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3491be7c6726750d2fac9871fa1d9c2622aa4bef

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In Plant Science

Citations in the corpus

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew (2014, positive): “Here we use transcription activator–like effector nuclease (TALEN) 2,3 and clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 (refs.”
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity (2013, background): “, 2011) and transcription-activator-like effector nucleases (TALENs) (Boch et al., 2009; Christian et al., 2010; Miller et al., 2011; Moscou and Bogdanove, 2009; Reyon et al., 2012; Sanjana et al., 2012; Wood et al., 2011; Zhang et al., 2011), wherein DNA cleavage requires synergistic interaction of”
A TALE nuclease architecture for efficient genome editing (2011, background): “Recently, two groups described an approach for engineering DNA-binding specificities based upon TALEs from Xanthomonas plant pathogen”
Genome Engineering With Zinc-Finger Nucleases (2011, background): “The TAL effector domain, found in some Xanthomonas proteins involved in manipulating host gene expression, is composed of modules of 34 amino acids, each of which contacts a single base pair (Boch et al. 2009; Moscou and Bogdanove 2009).”
Genome Engineering of Crops with Designer Nucleases (2012, background): “Recent computational and molecular biological analyses made it possible to decipher the TALE code for DNA recognition (Boch et al., 2009; Moscou and Bogdanove, 2009).”
Both CRISPR/Cas-based nucleases and nickases can be used efficiently for genome engineering in Arabidopsis thaliana. (2014, neutral): “than do ZFNs (Boch et al., 2009; Moscou and Bogdanove, 2009).”
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting (2011, methodology): “Members of our group and another lab independently discovered that a polymorphic pair of adjacent residues at positions 12 and 13 in each repeat, the ‘repeat-variable di-residue’ (RVD), specifies the target, one RVD to one nucleotide, with the four most common RVDs each preferentially associating wi”
Gene therapy clinical trials worldwide to 2017: An update (2018, background): “It is now approaching two decades since the first targeted nucleases were shown to bind DNA and create double strand breaks, which dramatically enhance site‐specific genome editing.(88-92) Alteration of the genome at the nuclease‐induced break can be used not only for gene addition and gene disrupti”
Genome Editing—Principles and Applications for Functional Genomics Research and Crop Improvement (2017, background): “For example, the RVDs His-Asp (HD), Asn-Ile (NI), Asn-Gly (NG) and Asn-Asn (NN) recognize the nucleotides C, A, T, and G, respectively (Boch et al., 2009; Moscou and Bogdanove, 2009; Deng et al., 2012a).”
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (2010, methodology): “Using this cipher, targets of new TALEs have been correctly predicted, and functional targets of TALEs composed of randomly assembled repeats have been generated (Boch et al. 2009; Moscou and Bogdanove 2009; Romer et al. 2010).”